Nature Communications (Nov 2022)
A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience
- Changnan Wang,
- Bingying Wang,
- Taruna Pandey,
- Yong Long,
- Jianxiu Zhang,
- Fiona Oh,
- Jessica Sima,
- Ruyin Guo,
- Yun Liu,
- Chao Zhang,
- Shaeri Mukherjee,
- Michael Bassik,
- Weichun Lin,
- Huichao Deng,
- Goncalo Vale,
- Jeffrey G. McDonald,
- Kang Shen,
- Dengke K. Ma
Affiliations
- Changnan Wang
- Cardiovascular Research Institute and Department of Physiology, University of California San Francisco
- Bingying Wang
- Cardiovascular Research Institute and Department of Physiology, University of California San Francisco
- Taruna Pandey
- Cardiovascular Research Institute and Department of Physiology, University of California San Francisco
- Yong Long
- State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences
- Jianxiu Zhang
- Department of Molecular and Cellular Physiology, Stanford University
- Fiona Oh
- Cardiovascular Research Institute and Department of Physiology, University of California San Francisco
- Jessica Sima
- Cardiovascular Research Institute and Department of Physiology, University of California San Francisco
- Ruyin Guo
- Cardiovascular Research Institute and Department of Physiology, University of California San Francisco
- Yun Liu
- Department of Neuroscience, University of Texas Southwestern Medical Center
- Chao Zhang
- Shanghai Institute of Precision Medicine, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
- Shaeri Mukherjee
- Department of Microbiology and Immunology, University of California, San Francisco
- Michael Bassik
- Department of Genetics, Stanford University School of Medicine
- Weichun Lin
- Department of Neuroscience, University of Texas Southwestern Medical Center
- Huichao Deng
- Department of Biology, Howard Hughes Medical Institute, Stanford University
- Goncalo Vale
- Center for Human Nutrition, University of Texas Southwestern Medical Center
- Jeffrey G. McDonald
- Center for Human Nutrition, University of Texas Southwestern Medical Center
- Kang Shen
- Department of Biology, Howard Hughes Medical Institute, Stanford University
- Dengke K. Ma
- Cardiovascular Research Institute and Department of Physiology, University of California San Francisco
- DOI
- https://doi.org/10.1038/s41467-022-34450-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
Environmental temperature changes can alter cell membrane lipid composition but the mechanisms underlying this conserved mechanism are unclear. Here, the authors identify the megaprotein LPD-3 in C. elegans as critical for normal phospholipid distribution and cold resilience.
