Nature Communications (Jul 2020)
Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma
- Wei Cao,
- Hayan Lee,
- Wei Wu,
- Aubhishek Zaman,
- Sean McCorkle,
- Ming Yan,
- Justin Chen,
- Qinghe Xing,
- Nasa Sinnott-Armstrong,
- Hongen Xu,
- M. Reza Sailani,
- Wenxue Tang,
- Yuanbo Cui,
- Jia liu,
- Hongyan Guan,
- Pengju Lv,
- Xiaoyan Sun,
- Lei Sun,
- Pengli Han,
- Yanan Lou,
- Jing Chang,
- Jinwu Wang,
- Yuchi Gao,
- Jiancheng Guo,
- Gundolf Schenk,
- Alan Hunter Shain,
- Fred G. Biddle,
- Eric Collisson,
- Michael Snyder,
- Trever G. Bivona
Affiliations
- Wei Cao
- Translational Medical Center, Zhengzhou Central Hospital Affiliated Zhengzhou University
- Hayan Lee
- Department of Genetics, School of Medicine
- Wei Wu
- Department of Medicine, University of California San Francisco
- Aubhishek Zaman
- Department of Medicine, University of California San Francisco
- Sean McCorkle
- Computational Science Initiative, Brookhaven National Laboratory
- Ming Yan
- Basic Medical College, Zhengzhou University
- Justin Chen
- Department of Genetics, School of Medicine
- Qinghe Xing
- Institutes of Biomedical Sciences and Children’s Hospital, Fudan University
- Nasa Sinnott-Armstrong
- Department of Genetics, School of Medicine
- Hongen Xu
- Precision Medicine Center, The Academy of Medical Sciences, Zhengzhou University
- M. Reza Sailani
- Department of Genetics, School of Medicine
- Wenxue Tang
- Precision Medicine Center, The Academy of Medical Sciences, Zhengzhou University
- Yuanbo Cui
- Translational Medical Center, Zhengzhou Central Hospital Affiliated Zhengzhou University
- Jia liu
- Translational Medical Center, Zhengzhou Central Hospital Affiliated Zhengzhou University
- Hongyan Guan
- Translational Medical Center, Zhengzhou Central Hospital Affiliated Zhengzhou University
- Pengju Lv
- Translational Medical Center, Zhengzhou Central Hospital Affiliated Zhengzhou University
- Xiaoyan Sun
- Translational Medical Center, Zhengzhou Central Hospital Affiliated Zhengzhou University
- Lei Sun
- Translational Medical Center, Zhengzhou Central Hospital Affiliated Zhengzhou University
- Pengli Han
- Translational Medical Center, Zhengzhou Central Hospital Affiliated Zhengzhou University
- Yanan Lou
- Translational Medical Center, Zhengzhou Central Hospital Affiliated Zhengzhou University
- Jing Chang
- Jiangsu Mai Jian Biotechnology Development Company
- Jinwu Wang
- Department of Pathology, Linzhou Cancer Hospital
- Yuchi Gao
- Annoroad Gene Company
- Jiancheng Guo
- Precision Medicine Center, The Academy of Medical Sciences, Zhengzhou University
- Gundolf Schenk
- Bakar Computational Health Sciences Institute, University of California San Francisco
- Alan Hunter Shain
- Department of Dermatology, University of California San Francisco
- Fred G. Biddle
- Department of Biological Sciences, University of Calgary
- Eric Collisson
- Department of Medicine, University of California San Francisco
- Michael Snyder
- Department of Genetics, School of Medicine
- Trever G. Bivona
- Department of Medicine, University of California San Francisco
- DOI
- https://doi.org/10.1038/s41467-020-17227-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 19
Abstract
The epigenetic landscape of esophageal squamous cell carcinoma (ESCC) at genome-wide high resolution is incompletely studied. Here, the authors performed an integrated multi-omics analysis of ESCC and non-tumor tissues to define the genome-wide methylome landscape and epigenetic alterations to uncover oncogenic drivers of ESCC.
