Children (Nov 2022)

Prevalence of High Blood Pressure in Pediatric Patients with Sleep-Disordered Breathing, Reversibility after Treatment: The KIDS TRIAL Study Protocol

  • María Castillo-García,
  • Esther Solano-Pérez,
  • Sofía Romero-Peralta,
  • María Esther Viejo-Ayuso,
  • Laura Silgado-Martínez,
  • Leticia Álvarez-Balado,
  • Rosa Mediano San Andrés,
  • Pilar Resano-Barrio,
  • Francisco García-Rio,
  • Irene Cano-Pumarega,
  • Manuel Sánchez-de-la-Torre,
  • Alfonso Ortigado,
  • Ana López-Dueñas,
  • Laura Fidalgo,
  • Ángel Rodríguez,
  • Olga Mediano,
  • Spanish Sleep Network

DOI
https://doi.org/10.3390/children9121849
Journal volume & issue
Vol. 9, no. 12
p. 1849

Abstract

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Current data support an increase in the prevalence of high blood pressure (HBP) in pediatric patients with sleep-disordered breathing (SDB). Adeno-tonsillectomy has been shown to be an effective treatment for most patients. Our objective was to determine the prevalence of HBP in pediatric patients with SDB and the impact of adeno-tonsillectomy with a multicenter, longitudinal, and prospective study that included 286 children referred for suspected SDB. The diagnosis of SDB was established by polysomnography (PSG) and the diagnosis of HBP by 24-h ambulatory blood pressure monitoring (ABPM). In patients without SDB and SDB without treatment indication, these tests were repeated six months after the baseline visit. For patients with medical treatment for SDB, the tests were repeated six months after the treatment initiation. Finally, in patients with surgery indication, ABPM was performed just before surgical treatment and ABPM and PSG six months after the intervention. The study contributes to elucidating the association between SDB and HBP in pediatric patients. Moreover, it contributes to determining if intervention with adeno-tonsillectomy is associated with BP reduction. The results have direct implications for the management of SDB, providing essential information on treatment indications for existing clinical guidelines. NCT03696654.

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