Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation

Lucie Laurien; Masahiro Nagata; Hannah Schünke; Tom Delanghe; Janica L. Wiederstein; Snehlata Kumari; Robin Schwarzer; Teresa Corona; Marcus Krüger; Mathieu J. M. Bertrand; Vangelis Kondylis; Manolis Pasparakis

doi:10.1038/s41467-020-15466-8

Nature Communications (Apr 2020)

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation

Lucie Laurien,
Masahiro Nagata,
Hannah Schünke,
Tom Delanghe,
Janica L. Wiederstein,
Snehlata Kumari,
Robin Schwarzer,
Teresa Corona,
Marcus Krüger,
Mathieu J. M. Bertrand,
Vangelis Kondylis,
Manolis Pasparakis

Affiliations

Lucie Laurien: Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Masahiro Nagata: Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Hannah Schünke: Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Tom Delanghe: VIB Center for Inflammation Research
Janica L. Wiederstein: Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Snehlata Kumari: Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Robin Schwarzer: Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Teresa Corona: Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Marcus Krüger: Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Mathieu J. M. Bertrand: VIB Center for Inflammation Research
Vangelis Kondylis: Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Manolis Pasparakis: Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne

DOI: https://doi.org/10.1038/s41467-020-15466-8
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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Receptor interacting protein kinase 1 (RIPK1) regulates cell death and inflammatory responses. Here the authors show that autophosphorylation at Ser166 is required for RIPK1-mediated cell death and inflammation in mouse models of inflammatory pathologies, making Ser166 phosphorylation a possible biomarker for RIPK1-mediated inflammatory diseases.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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