Research progress on common pathological types of somatic mutation in epilepsy surgery

Abstract

Epilepsy is a common neurological disease in clinic. Epilepsy caused by structural causes can be cured by surgery, which has been the focus of attention in the field of epilepsy surgery. With the development of gene sequencing technology, more and more studies have found that structural etiology may be caused by somatic mutations of genes. In this paper, somatic mutation⁃related pathogenic genes of four common pathological types of epilepsy surgery, including malformation of cortical development (MCD), long⁃term epilepsy associated tumor (LEAT), hippocampal sclerosis (HS) and hypothalamic hamartoma (HH), were reviewed, and their effects on surgical protocol formulation and prognosis were reviewed, in order to provide a new idea for the treatment of epilepsy.

Keywords

• epilepsy
• genes
• mutation
• pathology
• review