Nature Communications (Apr 2017)
A genome-wide association study identifies six novel risk loci for primary biliary cholangitis
- Fang Qiu,
- Ruqi Tang,
- Xianbo Zuo,
- Xingjuan Shi,
- Yiran Wei,
- Xiaodong Zheng,
- Yaping Dai,
- Yuhua Gong,
- Lan Wang,
- Ping Xu,
- Xiang Zhu,
- Jian Wu,
- Chongxu Han,
- Yueqiu Gao,
- Kui Zhang,
- Yuzhang Jiang,
- Jianbo Zhou,
- Youlin Shao,
- Zhigang Hu,
- Ye Tian,
- Haiyan Zhang,
- Na Dai,
- Lei Liu,
- Xudong Wu,
- Weifeng Zhao,
- Xiaomin Zhang,
- Zhidong Zang,
- Jinshan Nie,
- Weihao Sun,
- Yi Zhao,
- Yuan Mao,
- Po Jiang,
- Hualiang Ji,
- Qing Dong,
- Junming Li,
- Zhenzhong Li,
- Xinli Bai,
- Li Li,
- Maosong Lin,
- Ming Dong,
- Jinxin Li,
- Ping Zhu,
- Chan Wang,
- Yanqiu Zhang,
- Peng Jiang,
- Yujue Wang,
- Rohil Jawed,
- Jing Xu,
- Yu Zhang,
- Qixia Wang,
- Yue Yang,
- Fan Yang,
- Min Lian,
- Xiang Jiang,
- Xiao Xiao,
- Yanmei Li,
- Jingyuan Fang,
- Dekai Qiu,
- Zhen Zhu,
- Hong Qiu,
- Jianqiong Zhang,
- Wenyan Tian,
- Sufang Chen,
- Ling Jiang,
- Bing Ji,
- Ping Li,
- Guochang Chen,
- Tianxue Wu,
- Yan Sun,
- Jianjiang Yu,
- Huijun Tang,
- Michun He,
- Min Xia,
- Hao Pei,
- Lihua Huang,
- Zhuye Qing,
- Jianfang Wu,
- Qinghai Huang,
- Junhai Han,
- Wei Xie,
- Zhongsheng Sun,
- Jian Guo,
- Gengsheng He,
- M. Eric Gershwin,
- Zhexiong Lian,
- Xiang Liu,
- Michael F. Seldin,
- Xiangdong Liu,
- Weichang Chen,
- Xiong Ma
Affiliations
- Fang Qiu
- Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University
- Ruqi Tang
- Department of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease
- Xianbo Zuo
- Department of Dermatology at No. 1 Hospital, Institute of Dermatology, Anhui Medical University
- Xingjuan Shi
- Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University
- Yiran Wei
- Department of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease
- Xiaodong Zheng
- Department of Dermatology at No. 1 Hospital, Institute of Dermatology, Anhui Medical University
- Yaping Dai
- Department of Laboratory Medicine, The Fifth People’s Hospital of Wuxi
- Yuhua Gong
- Department of Laboratory Medicine, The Third People’s Hospital of Zhenjiang
- Lan Wang
- Department of Laboratory Medicine, The 81th Hospital of PLA
- Ping Xu
- Department of Laboratory Medicine, The Fifth People’s Hospital of Suzhou, Soochow University
- Xiang Zhu
- Department of Laboratory Medicine, The Fifth People’s Hospital of Suzhou, Soochow University
- Jian Wu
- Department of Rheumatology, Department of Gastroenterology, The First Affiliated Hospital of Soochow University
- Chongxu Han
- Department of Laboratory Medicine, Subei People’s Hospital, Clinical Medical College, Yangzhou University
- Yueqiu Gao
- Department of Hepatology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
- Kui Zhang
- Department of Laboratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
- Yuzhang Jiang
- Department of Laboratory Medicine, Huai’an First People’s Hospital, Nanjing Medical University
- Jianbo Zhou
- Department of Laboratory Medicine, Jiangyin People’s Hospital, Southeast University
- Youlin Shao
- Department of Laboratory Medicine, The Third People’s Hospital of Changzhou
- Zhigang Hu
- Department of Laboratory Medicine, Affiliated Wuxi People’s Hospital of Nanjing Medical University
- Ye Tian
- Department of Radiology, The Second Affiliated Hospital of Soochow University
- Haiyan Zhang
- Department of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease
- Na Dai
- Department of Gastroenterology, Jiangsu University affiliated Kunshan Hospital
- Lei Liu
- Department of Gastroenterology, Yixing People’s Hospital
- Xudong Wu
- Department of Gastroenterology, Yancheng First People’s Hospital
- Weifeng Zhao
- Department of Rheumatology, Department of Gastroenterology, The First Affiliated Hospital of Soochow University
- Xiaomin Zhang
- Department of Laboratory Medicine, The University Hospital, Southeast University
- Zhidong Zang
- Department of Hepatology, The Second Hospital of Nanjing, Southeast University
- Jinshan Nie
- Department of Gastroenterology, Taicang First People’s Hospital, Soochow University
- Weihao Sun
- Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University
- Yi Zhao
- Department of Gastroenterology, Eastern Hepatobiliary Surgery Hospital
- Yuan Mao
- Department of Immunology, Nanjing Kingmed Clinical Laboratory Co. Ltd.
- Po Jiang
- Department of Hepatology, The Second People’s Hospital of Jingjiang
- Hualiang Ji
- Department of Gastroenterology, Hai’an People’s Hospital, Nantong University Medical School
- Qing Dong
- Department of Laboratory Medicine, Suzhou Hospital of Traditional Chinese Medicine
- Junming Li
- Department of Laboratory Medicine, The First Affiliated Hospital of Nanchang University
- Zhenzhong Li
- Department of Paediatrics, The Second Hospital of Hebei Medical University
- Xinli Bai
- Department of Laboratory Medicine, Zhongda Hospital, School of Medicine, Southeast University
- Li Li
- Department of Gastroenterology, Taizhou People’s Hospital
- Maosong Lin
- Department of Hepatology, Traditional Chinese Medicine Hospital of Kunshan
- Ming Dong
- Department of Genomics and Epigenomics, Beijing Institutes of Life Science, Chinese Academy of Sciences
- Jinxin Li
- Department of Gerontology, Beijing Hospital
- Ping Zhu
- Department of Nutrition and Health, School of Public Health, Fudan University
- Chan Wang
- Division of Rheumatology, Allergy, and Clinical Immunology, Rowe Program in Genetics, University of California-Davis
- Yanqiu Zhang
- Department of Immunology, School of Life Sciences, University of Science and Technology of China
- Peng Jiang
- Department of Stomatology, The First Affiliated Hospital, Hainan Medical University
- Yujue Wang
- Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University
- Rohil Jawed
- Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University
- Jing Xu
- Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University
- Yu Zhang
- Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University
- Qixia Wang
- Department of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease
- Yue Yang
- Department of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease
- Fan Yang
- Department of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease
- Min Lian
- Department of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease
- Xiang Jiang
- Department of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease
- Xiao Xiao
- Department of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease
- Yanmei Li
- Department of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease
- Jingyuan Fang
- Department of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease
- Dekai Qiu
- Department of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease
- Zhen Zhu
- Department of Laboratory Medicine, The Third People’s Hospital of Changzhou
- Hong Qiu
- Department of Laboratory Medicine, The 81th Hospital of PLA
- Jianqiong Zhang
- Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University
- Wenyan Tian
- Department of Rheumatology, Department of Gastroenterology, The First Affiliated Hospital of Soochow University
- Sufang Chen
- Department of Laboratory Medicine, The Fifth People’s Hospital of Suzhou, Soochow University
- Ling Jiang
- Department of Rheumatology, Department of Gastroenterology, The First Affiliated Hospital of Soochow University
- Bing Ji
- Department of Laboratory Medicine, The 81th Hospital of PLA
- Ping Li
- Department of Laboratory Medicine, The 81th Hospital of PLA
- Guochang Chen
- Department of Laboratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
- Tianxue Wu
- Department of Laboratory Medicine, Subei People’s Hospital, Clinical Medical College, Yangzhou University
- Yan Sun
- Department of Laboratory Medicine, Subei People’s Hospital, Clinical Medical College, Yangzhou University
- Jianjiang Yu
- Department of Laboratory Medicine, Jiangyin People’s Hospital, Southeast University
- Huijun Tang
- Department of Laboratory Medicine, Jiangyin People’s Hospital, Southeast University
- Michun He
- Department of Rheumatology, Department of Gastroenterology, The First Affiliated Hospital of Soochow University
- Min Xia
- Department of Laboratory Medicine, Affiliated Wuxi People’s Hospital of Nanjing Medical University
- Hao Pei
- Department of Laboratory Medicine, The Fifth People’s Hospital of Wuxi
- Lihua Huang
- Department of Laboratory Medicine, The Fifth People’s Hospital of Wuxi
- Zhuye Qing
- Department of Immunology, Nanjing Kingmed Clinical Laboratory Co. Ltd.
- Jianfang Wu
- Department of Hepatology, Traditional Chinese Medicine Hospital of Kunshan
- Qinghai Huang
- Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University
- Junhai Han
- Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University
- Wei Xie
- Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University
- Zhongsheng Sun
- Department of Genomics and Epigenomics, Beijing Institutes of Life Science, Chinese Academy of Sciences
- Jian Guo
- Department of Gerontology, Beijing Hospital
- Gengsheng He
- Department of Nutrition and Health, School of Public Health, Fudan University
- M. Eric Gershwin
- Division of Rheumatology, Allergy, and Clinical Immunology, Rowe Program in Genetics, University of California-Davis
- Zhexiong Lian
- Department of Immunology, School of Life Sciences, University of Science and Technology of China
- Xiang Liu
- Department of Stomatology, The First Affiliated Hospital, Hainan Medical University
- Michael F. Seldin
- Division of Rheumatology, Allergy, and Clinical Immunology, Rowe Program in Genetics, University of California-Davis
- Xiangdong Liu
- Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University
- Weichang Chen
- Department of Rheumatology, Department of Gastroenterology, The First Affiliated Hospital of Soochow University
- Xiong Ma
- Department of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease
- DOI
- https://doi.org/10.1038/ncomms14828
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 8
Abstract
Primary biliary cholangitis is an autoimmune liver disease. Here, the authors show that variants in interleukin genes which potentially deregulate their expression are associated with this condition, and suggest that the IL21 signalling pathway may have a role in disease aetiology.
