Overexpression of Global Regulator SCrp Leads to the Discovery of New Angucyclines in <i>Streptomyces</i> sp. XS-16

Xiao Xu; Falei Zhang; Luning Zhou; Yimin Chang; Qian Che; Tianjiao Zhu; Dehai Li; Guojian Zhang

doi:10.3390/md21040240

Marine Drugs (Apr 2023)

Overexpression of Global Regulator SCrp Leads to the Discovery of New Angucyclines in <i>Streptomyces</i> sp. XS-16

Xiao Xu,
Falei Zhang,
Luning Zhou,
Yimin Chang,
Qian Che,
Tianjiao Zhu,
Dehai Li,
Guojian Zhang

Affiliations

Xiao Xu: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Falei Zhang: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Luning Zhou: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Yimin Chang: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Qian Che: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Tianjiao Zhu: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Dehai Li: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Guojian Zhang: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China

DOI: https://doi.org/10.3390/md21040240
Journal volume & issue: Vol. 21, no. 4
p. 240

Abstract

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Six angucyclines including three unreported compounds (1–3) were isolated from Streptomyces sp. XS-16 by overexpressing the native global regulator of SCrp (cyclic AMP receptor). The structures were characterized based on nuclear magnetic resonance (NMR) and spectrometry analysis and assisted by electronic circular dichroism (ECD) calculations. All compounds were tested for their antitumor and antimicrobial activities, and compound 1 showed different inhibitory activities against various tumor cell lines with IC50 values ranging from 0.32 to 5.33 μM.

Published in Marine Drugs

ISSN: 1660-3397 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/marinedrugs

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