Managing Renal Cell Carcinoma Associated Paraneoplastic Syndrome with Nephron-sparing Surgery in a Patient with von Hippel-Lindau

John M. DiBianco; Julie Y. An; Sally Tanakchi; Zachary Stanik; Aidan McGowan; Mahir Maruf; Abhinav Sidana; Amit Lodha Jain; Akhil Muthigi; Arvin K. George; Christopher Bayne; W. Marston Linehan; Shawna L. Boyle; Adam R. Metwalli

doi:10.1016/j.eucr.2017.02.015

Urology Case Reports (Jul 2017)

Managing Renal Cell Carcinoma Associated Paraneoplastic Syndrome with Nephron-sparing Surgery in a Patient with von Hippel-Lindau

John M. DiBianco,
Julie Y. An,
Sally Tanakchi,
Zachary Stanik,
Aidan McGowan,
Mahir Maruf,
Abhinav Sidana,
Amit Lodha Jain,
Akhil Muthigi,
Arvin K. George,
Christopher Bayne,
W. Marston Linehan,
Shawna L. Boyle,
Adam R. Metwalli

Affiliations

John M. DiBianco: School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA
Julie Y. An: Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bldg. 10, Hatfield Clinical Research Center, Rm 2 W-3952 10 Center Drive MSC 1210, 20892-1210, Bethesda, MD, USA
Sally Tanakchi: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Zachary Stanik: Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bldg. 10, Hatfield Clinical Research Center, Rm 2 W-3952 10 Center Drive MSC 1210, 20892-1210, Bethesda, MD, USA
Aidan McGowan: Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bldg. 10, Hatfield Clinical Research Center, Rm 2 W-3952 10 Center Drive MSC 1210, 20892-1210, Bethesda, MD, USA
Mahir Maruf: Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bldg. 10, Hatfield Clinical Research Center, Rm 2 W-3952 10 Center Drive MSC 1210, 20892-1210, Bethesda, MD, USA
Abhinav Sidana: Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bldg. 10, Hatfield Clinical Research Center, Rm 2 W-3952 10 Center Drive MSC 1210, 20892-1210, Bethesda, MD, USA
Amit Lodha Jain: Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bldg. 10, Hatfield Clinical Research Center, Rm 2 W-3952 10 Center Drive MSC 1210, 20892-1210, Bethesda, MD, USA
Akhil Muthigi: Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bldg. 10, Hatfield Clinical Research Center, Rm 2 W-3952 10 Center Drive MSC 1210, 20892-1210, Bethesda, MD, USA
Arvin K. George: Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bldg. 10, Hatfield Clinical Research Center, Rm 2 W-3952 10 Center Drive MSC 1210, 20892-1210, Bethesda, MD, USA
Christopher Bayne: School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA
W. Marston Linehan: Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bldg. 10, Hatfield Clinical Research Center, Rm 2 W-3952 10 Center Drive MSC 1210, 20892-1210, Bethesda, MD, USA
Shawna L. Boyle: Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bldg. 10, Hatfield Clinical Research Center, Rm 2 W-3952 10 Center Drive MSC 1210, 20892-1210, Bethesda, MD, USA
Adam R. Metwalli: Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bldg. 10, Hatfield Clinical Research Center, Rm 2 W-3952 10 Center Drive MSC 1210, 20892-1210, Bethesda, MD, USA

DOI: https://doi.org/10.1016/j.eucr.2017.02.015
Journal volume & issue: Vol. 13, no. C
pp. 101 – 103

Abstract

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A patient with germline von Hippel-Lindau (VHL) gene alteration and history of multiple tumors present with classical paraneoplastic syndrome (PNS) associated with renal cell carcinoma (RCC). She underwent open nephron sparing surgery with resolution of symptoms. She remained without recurrence of RCC for the initial 2 years of her follow-up. To the best of our knowledge, this case represents the first in which PNS was specifically resolved using a partial nephrectomy in a patient with VHL. This case report provides initial evidence for the potential role of nephron sparing surgery in the management of paraneoplastic symptoms associated with hereditary RCC.

Published in Urology Case Reports

ISSN: 2214-4420 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the genitourinary system. Urology
Website: http://www.urologycasereports.com/

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