Nature Communications (May 2021)
A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation
- Sisi Kang,
- Mei Yang,
- Suhua He,
- Yueming Wang,
- Xiaoxue Chen,
- Yao-Qing Chen,
- Zhongsi Hong,
- Jing Liu,
- Guanmin Jiang,
- Qiuyue Chen,
- Ziliang Zhou,
- Zhechong Zhou,
- Zhaoxia Huang,
- Xi Huang,
- Huanhuan He,
- Weihong Zheng,
- Hua-Xin Liao,
- Fei Xiao,
- Hong Shan,
- Shoudeng Chen
Affiliations
- Sisi Kang
- Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University
- Mei Yang
- Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University
- Suhua He
- Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University
- Yueming Wang
- Institute of Biomedicine, Jinan University
- Xiaoxue Chen
- Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University
- Yao-Qing Chen
- School of Public Health (Shenzhen), Sun Yat-sen University
- Zhongsi Hong
- Department of Infectious Disease, The Fifth Affiliated Hospital, Sun Yat-sen University
- Jing Liu
- Department of Respiratory Disease, The Fifth Affiliated Hospital, Sun Yat-sen University
- Guanmin Jiang
- Department of Clinical laboratory, The Fifth Affiliated Hospital of Sun Yat-sen University
- Qiuyue Chen
- Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University
- Ziliang Zhou
- Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University
- Zhechong Zhou
- Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University
- Zhaoxia Huang
- Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University
- Xi Huang
- Center for Infection and Immunity, The Fifth Affiliated Hospital, Sun Yat-sen University
- Huanhuan He
- Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University
- Weihong Zheng
- Institute of Biomedicine, Jinan University
- Hua-Xin Liao
- Institute of Biomedicine, Jinan University
- Fei Xiao
- Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University
- Hong Shan
- Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University
- Shoudeng Chen
- Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University
- DOI
- https://doi.org/10.1038/s41467-021-23036-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
While SARS-CoV-2 S protein targeting monoclonal antibodies (mAbs) are well studied, little is known about N protein-targeting mAbs. Here, Kang et al. provide the crystal structure of the N protein RNA binding domain with a mAb derived from a convalescent patient and show that it compromises the N protein-induced complement hyperactivation.
