UVA-Triggered Drug Release and Photo-Protection of Skin

Vega Widya Karisma; Wei Wu; Mingxing Lei; Huawen Liu; Muhammad Farrukh Nisar; Matthew D. Lloyd; Charareh Pourzand; Charareh Pourzand; Julia Li Zhong

doi:10.3389/fcell.2021.598717

Frontiers in Cell and Developmental Biology (Feb 2021)

UVA-Triggered Drug Release and Photo-Protection of Skin

Vega Widya Karisma,
Wei Wu,
Mingxing Lei,
Huawen Liu,
Muhammad Farrukh Nisar,
Matthew D. Lloyd,
Charareh Pourzand,
Charareh Pourzand,
Julia Li Zhong

Affiliations

Vega Widya Karisma: Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing, China
Wei Wu: Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing, China
Mingxing Lei: Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing, China
Huawen Liu: Three Gorges Central Hospital, Chongqing, China
Muhammad Farrukh Nisar: Department of Physiology and Biochemistry, Cholistan University of Veterinary and Animal Sciences (CUVAS), Bahawalpur, Pakistan
Matthew D. Lloyd: Drug and Target Discovery, Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
Charareh Pourzand: Medicines Design, Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
Charareh Pourzand: Medicines Development, Centre for Therapeutic Innovation, University of Bath, Bath, United Kingdom
Julia Li Zhong: Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing, China

DOI: https://doi.org/10.3389/fcell.2021.598717
Journal volume & issue: Vol. 9

Abstract

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Light has attracted special attention as a stimulus for triggered drug delivery systems (DDS) due to its intrinsic features of being spatially and temporally tunable. Ultraviolet A (UVA) radiation has recently been used as a source of external light stimuli to control the release of drugs using a “switch on- switch off” procedure. This review discusses the promising potential of UVA radiation as the light source of choice for photo-controlled drug release from a range of photo-responsive and photolabile nanostructures via photo-isomerization, photo-cleavage, photo-crosslinking, and photo-induced rearrangement. In addition to its clinical use, we will also provide here an overview of the recent UVA-responsive drug release approaches that are developed for phototherapy and skin photoprotection.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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