Communications Biology (Jan 2021)

LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes

  • Carl Herdenberg,
  • Pascal M. Mutie,
  • Ola Billing,
  • Ahmad Abdullah,
  • Rona J. Strawbridge,
  • Ingrid Dahlman,
  • Simon Tuck,
  • Camilla Holmlund,
  • Peter Arner,
  • Roger Henriksson,
  • Paul W. Franks,
  • Håkan Hedman

DOI
https://doi.org/10.1038/s42003-020-01613-w
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 15

Abstract

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Herdenberg et al. show that adipogenesis and BMP signaling are altered in mouse cells deficient in LRIG (Leucine-rich repeats and immunoglobulin-like domains) proteins. They find that mutant LRIG/sma-10 variant worms exhibit lipid storage defects and that human LRIG1 variants are associated with higher body mass index, yet protect against type 2 diabetes. This study suggests an evolutionarily conserved role of LRIG proteins for lipid metabolism and BMP signaling.