Frontiers in Neuroscience (Jul 2019)

Performing Sparse Regularization and Dimension Reduction Simultaneously in Multimodal Data Fusion

  • Zhengshi Yang,
  • Xiaowei Zhuang,
  • Christopher Bird,
  • Karthik Sreenivasan,
  • Virendra Mishra,
  • Sarah Banks,
  • Dietmar Cordes,
  • Dietmar Cordes,
  • the Alzheimer's Disease Neuroimaging Initiative,
  • Michael W. Weiner,
  • Paul Aisen,
  • Michael Weiner,
  • Paul Aisen,
  • Ronald Petersen,
  • Clifford R. Jack,
  • William Jagust,
  • John Q. Trojanowki,
  • Arthur W. Toga,
  • Laurel Beckett,
  • Robert C. Green,
  • Andrew J. Saykin,
  • John Morris,
  • Leslie M. Shaw,
  • Zaven Khachaturian,
  • Greg Sorensen,
  • Maria Carrillo,
  • Lew Kuller,
  • Marc Raichle,
  • Steven Paul,
  • Peter Davies,
  • Howard Fillit,
  • Franz Hefti,
  • David Holtzman,
  • M. Marcel Mesulam,
  • William Potter,
  • Peter Snyder,
  • Adam Schwartz,
  • Robert C. Green,
  • Tom Montine,
  • Ronald Petersen,
  • Paul Aisen,
  • Ronald G. Thomas,
  • Michael Donohue,
  • Sarah Walter,
  • Devon Gessert,
  • Tamie Sather,
  • Gus Jiminez,
  • Archana B. Balasubramanian,
  • Jennifer Mason,
  • Iris Sim,
  • Laurel Beckett,
  • Danielle Harvey,
  • Michael Donohue,
  • Clifford R. Jack,
  • Matthew Bernstein,
  • Nick Fox,
  • Paul Thompson,
  • Norbert Schuff,
  • Charles DeCArli,
  • Bret Borowski,
  • Jeff Gunter,
  • Matt Senjem,
  • Prashanthi Vemuri,
  • David Jones,
  • Kejal Kantarci,
  • Chad Ward,
  • William Jagust,
  • Robert A. Koeppe,
  • Norm Foster,
  • Eric M. Reiman,
  • Kewei Chen,
  • Chet Mathis,
  • Susan Landau,
  • John C. Morris,
  • Nigel J. Cairns,
  • Erin Franklin,
  • Lisa Taylor-Reinwald,
  • Leslie M. Shaw,
  • John Q. Trojanowki,
  • Virginia Lee,
  • Magdalena Korecka,
  • Michal Figurski,
  • Arthur W. Toga,
  • Karen Crawford,
  • Scott Neu,
  • Andrew J. Saykin,
  • Tatiana M. Foroud,
  • Steven Potkin,
  • Li Shen,
  • Kelley Faber,
  • Sungeun Kim,
  • Kwangsik Nho,
  • Michael W. Weiner,
  • Lean Thal,
  • Zaven Khachaturian,
  • Leon Thal,
  • Neil Buckholtz,
  • Michael W. Weiner,
  • Peter J. Snyder,
  • William Potter,
  • Steven Paul,
  • Marilyn Albert,
  • Richard Frank,
  • Zaven Khachaturian,
  • John Hsiao,
  • Jeffrey Kaye,
  • Joseph Quinn,
  • Lisa Silbert,
  • Betty Lind,
  • Raina Carter,
  • Sara Dolen,
  • Lon S. Schneider,
  • Sonia Pawluczyk,
  • Mauricio Becerra,
  • Liberty Teodoro,
  • Bryan M. Spann,
  • James Brewer,
  • Helen Vanderswag,
  • Adam Fleisher,
  • Judith L. Heidebrink,
  • Joanne L. Lord,
  • Ronald Petersen,
  • Sara S. Mason,
  • Colleen S. Albers,
  • David Knopman,
  • Kris Johnson,
  • Rachelle S. Doody,
  • Javier Villanueva-Meyer,
  • Valory Pavlik,
  • Victoria Shibley,
  • Munir Chowdhury,
  • Susan Rountree,
  • Mimi Dang,
  • Yaakov Stern,
  • Lawrence S. Honig,
  • Karen L. Bell,
  • Beau Ances,
  • John C. Morris,
  • Maria Carroll,
  • Mary L. Creech,
  • Erin Franklin,
  • Mark A. Mintun,
  • Stacy Schneider,
  • Angela Oliver,
  • Daniel Marson,
  • David Geldmacher,
  • Marissa Natelson Love,
  • Randall Griffith,
  • David Clark,
  • John Brockington,
  • Erik Roberson,
  • Hillel Grossman,
  • Effie Mitsis,
  • Raj C. Shah,
  • Leyla deToledo-Morrell,
  • Ranjan Duara,
  • Maria T. Greig-Custo,
  • Warren Barker,
  • Marilyn Albert,
  • Chiadi Onyike,
  • Daniel D'Agostino,
  • Stephanie Kielb,
  • Martin Sadowski,
  • Mohammed O. Sheikh,
  • Ulysse Anaztasia,
  • Gaikwad Mrunalini,
  • P. Murali Doraiswamy,
  • Jeffrey R. Petrella,
  • Salvador Borges-Neto,
  • Terence Z. Wong,
  • Edward Coleman,
  • Steven E. Arnold,
  • Jason H. Karlawish,
  • David A. Wolk,
  • Christopher M. Clark,
  • Charles D. Smith,
  • Greg Jicha,
  • Peter Hardy,
  • Partha Sinha,
  • Elizabeth Oates,
  • Gary Conrad,
  • Oscar L. Lopez,
  • MaryAnn Oakley,
  • Donna M. Simpson,
  • Anton P. Porsteinsson,
  • Bonnie S. Goldstein,
  • Kim Martin,
  • Kelly M. Makino,
  • M. Saleem Ismail,
  • Connie Brand,
  • Steven G. Potkin,
  • Adrian Preda,
  • Dana Nguyen,
  • Kyle Womack,
  • Dana Mathews,
  • Mary Quiceno,
  • Allan I. Levey,
  • James J. Lah,
  • Janet S. Cellar,
  • Jeffrey M. Burns,
  • Russell H. Swerdlow,
  • William M. Brooks,
  • Liana Apostolova,
  • Kathleen Tingus,
  • Ellen Woo,
  • Daniel H.S. Silverman,
  • Po H. Lu,
  • George Bartzokis,
  • Neill R Graff-Radford,
  • Francine Parfitt,
  • Kim Poki-Walker,
  • Martin R. Farlow,
  • Ann Marie Hake,
  • Brandy R. Matthews,
  • Jared R. Brosch,
  • Scott Herring,
  • Christopher H. van Dyck,
  • Richard E. Carson,
  • Martha G. MacAvoy,
  • Pradeep Varma,
  • Howard Chertkow,
  • Howard Bergman,
  • Chris Hosein,
  • Sandra Black,
  • Bojana Stefanovic,
  • Curtis Caldwell,
  • Ging-Yuek Robin Hsiung,
  • Benita Mudge,
  • Vesna Sossi,
  • Howard Feldman,
  • Michele Assaly,
  • Elizabeth Finger,
  • Stephen Pasternack,
  • Irina Rachisky,
  • Dick Trost,
  • Andrew Kertesz,
  • Charles Bernick,
  • Donna Munic,
  • Marek-Marsel Mesulam,
  • Emily Rogalski,
  • Kristine Lipowski,
  • Sandra Weintraub,
  • Borna Bonakdarpour,
  • Diana Kerwin,
  • Chuang-Kuo Wu,
  • Nancy Johnson,
  • Carl Sadowsky,
  • Teresa Villena,
  • Raymond Scott Turner,
  • Kathleen Johnson,
  • Brigid Reynolds,
  • Reisa A. Sperling,
  • Keith A. Johnson,
  • Gad Marshall,
  • Jerome Yesavage,
  • Joy L. Taylor,
  • Barton Lane,
  • Allyson Rosen,
  • Jared Tinklenberg,
  • Marwan N. Sabbagh,
  • Christine M. Belden,
  • Sandra A. Jacobson,
  • Sherye A. Sirrel,
  • Neil Kowall,
  • Ronald Killiany,
  • Andrew E. Budson,
  • Alexander Norbash,
  • Patricia Lynn Johnson,
  • Thomas O. Obisesan,
  • Saba Wolday,
  • Joanne Allard,
  • Alan Lerner,
  • Paula Ogrocki,
  • Curtis Tatsuoka,
  • Parianne Fatica,
  • Evan Fletcher,
  • Pauline Maillard,
  • John Olichney,
  • Charles DeCarli,
  • Owen Carmichael,
  • Smita Kittur,
  • Michael Borrie,
  • T-Y Lee,
  • Rob Bartha,
  • Sterling Johnson,
  • Sanjay Asthana,
  • Cynthia M. Carlsson,
  • Steven G. Potkin,
  • Adrian Preda,
  • Dana Nguyen,
  • Pierre Tariot,
  • Anna Burke,
  • Ann Marie Milliken,
  • Nadira Trncic,
  • Adam Fleisher,
  • Stephanie Reeder,
  • Vernice Bates,
  • Horacio Capote,
  • Michelle Rainka,
  • Douglas W. Scharre,
  • Maria Kataki,
  • Brendan Kelley,
  • Earl A. Zimmerman,
  • Dzintra Celmins,
  • Alice D. Brown,
  • Godfrey D. Pearlson,
  • Karen Blank,
  • Karen Anderson,
  • Laura A. Flashman,
  • Marc Seltzer,
  • Mary L. Hynes,
  • Robert B. Santulli,
  • Kaycee M. Sink,
  • Gordineer Leslie,
  • Jeff D. Williamson,
  • Pradeep Garg,
  • Franklin Watkins,
  • Brian R. Ott,
  • Geoffrey Tremont,
  • Lori A. Daiello,
  • Stephen Salloway,
  • Paul Malloy,
  • Stephen Correia,
  • Howard J. Rosen,
  • Bruce L. Miller,
  • David Perry,
  • Jacobo Mintzer,
  • Kenneth Spicer,
  • David Bachman,
  • Elizabeth Finger,
  • Stephen Pasternak,
  • Irina Rachinsky,
  • John Rogers,
  • Andrew Kertesz,
  • Dick Drost,
  • Nunzio Pomara,
  • Raymundo Hernando,
  • Antero Sarrael,
  • Susan K. Schultz,
  • Karen Ekstam Smith,
  • Hristina Koleva,
  • Ki Won Nam,
  • Hyungsub Shim,
  • Norman Relkin,
  • Gloria Chiang,
  • Michael Lin,
  • Lisa Ravdin,
  • Amanda Smith,
  • Balebail Ashok Raj,
  • Kristin Fargher,
  • Michael W. Weiner,
  • Paul Aisen,
  • Michael Weiner,
  • Paul Aisen,
  • Ronald Petersen,
  • Robert C. Green,
  • Danielle Harvey,
  • Clifford R. Jack,
  • William Jagust,
  • John C. Morris,
  • Andrew J. Saykin,
  • Leslie M. Shaw,
  • Arthur W. Toga,
  • John Q. Trojanowki,
  • Thomas Neylan,
  • Jordan Grafman,
  • Robert C. Green,
  • Tom Montine,
  • Michael Weiner,
  • Ronald Petersen,
  • Paul Aisen,
  • Ronald G. Thomas,
  • Michael Donohue,
  • Gessert Devon,
  • Tamie Sather,
  • Davis Melissa,
  • Rosemary Morrison,
  • Gus Jiminez,
  • Thomas Neylan,
  • Hayes Jacqueline,
  • Finley Shannon,
  • Danielle Harvey,
  • Michael Donohue,
  • Clifford R. Jack,
  • Matthew Bernstein,
  • Bret Borowski,
  • Jeff Gunter,
  • Matt Senjem,
  • Kantarci Kejal,
  • Ward Chad,
  • William Jagust,
  • Robert A. Koeppe,
  • Norm Foster,
  • Eric M. Reiman,
  • Kewei Chen,
  • Susan Landau,
  • John C. Morris,
  • Nigel J. Cairns,
  • Erin Householder,
  • Leslie M. Shaw,
  • John Q. Trojanowki,
  • Virginia Lee,
  • Magdalena Korecka,
  • Michal Figurski,
  • Arthur W. Toga,
  • Crawford Karen,
  • Neu Scott,
  • Andrew J. Saykin,
  • Tatiana M. Foroud,
  • Steven Potkin,
  • Li Shen,
  • Kelley Faber,
  • Sungeun Kim,
  • Kwangsik Nho,
  • Michael W. Weiner,
  • Friedl Karl,
  • Lon S. Schneider,
  • Sonia Pawluczyk,
  • Becerra Mauricio,
  • James Brewer,
  • Helen Vanderswag,
  • Yaakov Stern,
  • Lawrence S. Honig,
  • Karen L. Bell,
  • Debra Fleischman,
  • Konstantinos Arfanakis,
  • Raj C. Shah,
  • Ranjan Duara,
  • Daniel Varon,
  • Maria T Greig,
  • P. Murali Doraiswamy,
  • Jeffrey R. Petrella,
  • Olga James,
  • Anton P. Porsteinsson,
  • Bonnie Goldstein,
  • Kimberly S. Martin,
  • Steven G. Potkin,
  • Adrian Preda,
  • Dana Nguyen,
  • Jacobo Mintzer,
  • Dino Massoglia,
  • Olga Brawman-Mintzer,
  • Carl Sadowsky,
  • Walter Martinez,
  • Teresa Villena,
  • William Jagust,
  • Susan Landau,
  • Howard Rosen,
  • David Perry,
  • Raymond Scott Turner,
  • Kelly Behan,
  • Brigid Reynolds,
  • Reisa A. Sperling,
  • Keith A. Johnson,
  • Gad Marshall,
  • Marwan N. Sabbagh,
  • Sandra A. Jacobson,
  • Sherye A. Sirrel,
  • Thomas O. Obisesan,
  • Saba Wolday,
  • Joanne Allard,
  • Sterling C. Johnson,
  • J. Jay Fruehling,
  • Sandra Harding,
  • Elaine R. Peskind,
  • Eric C. Petrie,
  • Gail Li,
  • Jerome A. Yesavage,
  • Joy L. Taylor,
  • Ansgar J. Furst,
  • Steven Chao,
  • Norman Relkin,
  • Gloria Chiang,
  • Lisa Ravdin,
  • Lisa Ravdin,
  • Scott Mackin,
  • Paul Aisen,
  • Rema Raman,
  • Scott Mackin,
  • Michael Weiner,
  • Paul Aisen,
  • Rema Raman,
  • Clifford R. Jack,
  • Susan Landau,
  • Andrew J. Saykin,
  • Arthur W. Toga,
  • Charles DeCarli,
  • Robert A. Koeppe,
  • Robert C. Green,
  • Erin Drake,
  • Michael Weiner,
  • Paul Aisen,
  • Rema Raman,
  • Mike Donohue,
  • Gustavo Jimenez,
  • Devon Gessert,
  • Kelly Harless,
  • Jennifer Salazar,
  • Yuliana Cabrera,
  • Sarah Walter,
  • Lindsey Hergesheimer,
  • Elizabeth Shaffer,
  • Scott Mackin,
  • Craig Nelson,
  • David Bickford,
  • Meryl Butters,
  • Michelle Zmuda,
  • Clifford R. Jack,
  • Matthew Bernstein,
  • Bret Borowski,
  • Jeff Gunter,
  • Matt Senjem,
  • Kejal Kantarci,
  • Chad Ward,
  • Denise Reyes,
  • Robert A. Koeppe,
  • Susan Landau,
  • Arthur W. Toga,
  • Karen Crawford,
  • Scott Neu,
  • Andrew J. Saykin,
  • Tatiana M. Foroud,
  • Kelley M. Faber,
  • Kwangsik Nho,
  • Kelly N. Nudelman,
  • Scott Mackin,
  • Howard Rosen,
  • Craig Nelson,
  • David Bickford,
  • Yiu Ho Au,
  • Kelly Scherer,
  • Daniel Catalinotto,
  • Samuel Stark,
  • Elise Ong,
  • Dariella Fernandez,
  • Meryl Butters,
  • Michelle Zmuda,
  • Oscar L. Lopez,
  • MaryAnn Oakley,
  • Donna M. Simpson

DOI
https://doi.org/10.3389/fnins.2019.00642
Journal volume & issue
Vol. 13

Abstract

Read online

Collecting multiple modalities of neuroimaging data on the same subject is increasingly becoming the norm in clinical practice and research. Fusing multiple modalities to find related patterns is a challenge in neuroimaging analysis. Canonical correlation analysis (CCA) is commonly used as a symmetric data fusion technique to find related patterns among multiple modalities. In CCA-based data fusion, principal component analysis (PCA) is frequently applied as a preprocessing step to reduce data dimension followed by CCA on dimension-reduced data. PCA, however, does not differentiate between informative voxels from non-informative voxels in the dimension reduction step. Sparse PCA (sPCA) extends traditional PCA by adding sparse regularization that assigns zero weights to non-informative voxels. In this study, sPCA is incorporated into CCA-based fusion analysis and applied on neuroimaging data. A cross-validation method is developed and validated to optimize the parameters in sPCA. Different simulations are carried out to evaluate the improvement by introducing sparsity constraint to PCA. Four fusion methods including sPCA+CCA, PCA+CCA, parallel ICA and sparse CCA were applied on structural and functional magnetic resonance imaging data of mild cognitive impairment subjects and normal controls. Our results indicate that sPCA significantly can reduce the impact of non-informative voxels and lead to improved statistical power in uncovering disease-related patterns by a fusion analysis.

Keywords