Nature Communications (May 2022)

Identification of a modulator of the actin cytoskeleton, mitochondria, nutrient metabolism and lifespan in yeast

  • Cierra N. Sing,
  • Enrique J. Garcia,
  • Thomas G. Lipkin,
  • Thomas M. Huckaba,
  • Catherine A. Tsang,
  • Arielle C. Coughlin,
  • Emily J. Yang,
  • Istvan R. Boldogh,
  • Ryo Higuchi-Sanabria,
  • Liza A. Pon

DOI
https://doi.org/10.1038/s41467-022-30045-9
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

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Actin cables affect lifespan by supporting movement and inheritance of fitter mitochondria to daughter cells in yeast. Here the authors show that branched-chain amino acid (BCAA) levels affect actin cable stability and a role for YKL075C/AAN1 in control of BCAA metabolism and actin cable stability and function.