An experimental model of endoscopic argon plasma coagulation in liquid medium

Abstract

The aim of the research was to investigate the effect of argon plasma coagulation on the wall of the gastrointestinal tract in experiment. Material and methods. A method of endoscopic argon plasma coagulation in a liquid medium was developed to eliminate the shortcomings of the standard technology. Rabbits, divided into two groups, were used as experimental animals; the developed technology of argon plasma coagulation in a liquid medium was applied in the treatment group, while the standard technology of argon plasma coagulation was used in the control group. Gastroscopy, with focal application of argon plasma coagulation followed by morphological examination of the coagulation zones after 1 hour, 1 day, 3 days, and 5 days, was performed. Results. Analysis of morphological sections indicates that when using argon plasma coagulation in a liquid medium, the depth of coagulation impact on biological tissues decreases, as well as the severity of inflammatory changes, resulting in faster reparative changes. The obtained results may be of interest for further clinical-experimental research and implementation into clinical practice of modifications of endoscopic argon plasma coagulation.

Keywords

• peptic ulcer bleeding
• argon plasma coagulation
• endoscopic hemostasis