The superantigens SpeC and TSST-1 specifically activate TRBV12-3/12-4+ memory T cells

Freya R. Shepherd; Kate Davies; Kelly L. Miners; Sian Llewellyn-Lacey; Simon Kollnberger; James E. Redman; Melissa M. Grant; Kristin Ladell; David A. Price; James E. McLaren

doi:10.1038/s42003-023-04420-1

Communications Biology (Jan 2023)

The superantigens SpeC and TSST-1 specifically activate TRBV12-3/12-4+ memory T cells

Freya R. Shepherd,
Kate Davies,
Kelly L. Miners,
Sian Llewellyn-Lacey,
Simon Kollnberger,
James E. Redman,
Melissa M. Grant,
Kristin Ladell,
David A. Price,
James E. McLaren

Affiliations

Freya R. Shepherd: Division of Infection and Immunity, School of Medicine, Cardiff University
Kate Davies: Division of Infection and Immunity, School of Medicine, Cardiff University
Kelly L. Miners: Division of Infection and Immunity, School of Medicine, Cardiff University
Sian Llewellyn-Lacey: Division of Infection and Immunity, School of Medicine, Cardiff University
Simon Kollnberger: Division of Infection and Immunity, School of Medicine, Cardiff University
James E. Redman: School of Chemistry, Cardiff University
Melissa M. Grant: School of Dentistry, Institute of Clinical Sciences, University of Birmingham
Kristin Ladell: Division of Infection and Immunity, School of Medicine, Cardiff University
David A. Price: Division of Infection and Immunity, School of Medicine, Cardiff University
James E. McLaren: Division of Infection and Immunity, School of Medicine, Cardiff University

DOI: https://doi.org/10.1038/s42003-023-04420-1
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 12

Abstract

Read online

In peripheral blood mononuclear cells from healthy human donors, the superantigens SpeC and TSST-1 are shown to specifically activate TRBV12-3/12-4+ memory T cells.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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