Nature Communications (Jun 2021)
A functional motif of long noncoding RNA Nron against osteoporosis
- Fujun Jin,
- Junhui Li,
- Yong-Biao Zhang,
- Xiangning Liu,
- Mingxiang Cai,
- Meijing Liu,
- Mengyao Li,
- Cui Ma,
- Rui Yue,
- Yexuan Zhu,
- Renfa Lai,
- Zuolin Wang,
- Xunming Ji,
- Huawei Wei,
- Jun Dong,
- Zhiduo Liu,
- Yifei Wang,
- Yao Sun,
- Xiaogang Wang
Affiliations
- Fujun Jin
- Clinical Research Platform for Interdiscipline of Stomatology, The First Affiliated Hospital of Jinan University & Department of Stomatology, College of stomatology, Jinan University
- Junhui Li
- Department of Oral Implantology, School of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration
- Yong-Biao Zhang
- Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Engineering Medicine, Beihang University
- Xiangning Liu
- Clinical Research Platform for Interdiscipline of Stomatology, The First Affiliated Hospital of Jinan University & Department of Stomatology, College of stomatology, Jinan University
- Mingxiang Cai
- Clinical Research Platform for Interdiscipline of Stomatology, The First Affiliated Hospital of Jinan University & Department of Stomatology, College of stomatology, Jinan University
- Meijing Liu
- Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Engineering Medicine, Beihang University
- Mengyao Li
- Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine
- Cui Ma
- Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Engineering Medicine, Beihang University
- Rui Yue
- Institute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University
- Yexuan Zhu
- Guangzhou Jinan Biomedicine Research and Development Center, National Engineering Research Center of Genetic Medicine, Institute of Biomedicine, College of Life Science and Technology, Jinan University
- Renfa Lai
- Clinical Research Platform for Interdiscipline of Stomatology, The First Affiliated Hospital of Jinan University & Department of Stomatology, College of stomatology, Jinan University
- Zuolin Wang
- Department of Oral Implantology, School of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration
- Xunming Ji
- Department of Neurosurgery & China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University
- Huawei Wei
- Zeki Biotechnology & Pharmaceutical Co. Ltd
- Jun Dong
- Guangzhou Jinan Biomedicine Research and Development Center, National Engineering Research Center of Genetic Medicine, Institute of Biomedicine, College of Life Science and Technology, Jinan University
- Zhiduo Liu
- Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine
- Yifei Wang
- Guangzhou Jinan Biomedicine Research and Development Center, National Engineering Research Center of Genetic Medicine, Institute of Biomedicine, College of Life Science and Technology, Jinan University
- Yao Sun
- Department of Oral Implantology, School of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration
- Xiaogang Wang
- Clinical Research Platform for Interdiscipline of Stomatology, The First Affiliated Hospital of Jinan University & Department of Stomatology, College of stomatology, Jinan University
- DOI
- https://doi.org/10.1038/s41467-021-23642-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
LncRNAs are implicated in the pathogenesis of a number of diseases. Here, the authors show that the lncRNA Nron suppresses bone resorption, and show that delivery of a functional motif of Nron increases bone mass in mouse models of osteoporosis.
