Observational study between level of vitamin D, anthropometric status and metabolic profiles in patients with type 2 diabetes mellitus

Abstract

Introduction. Type 2 diabetes mellitus (T2DM) is currently an important global health disease. At the same time vitamin D deficiency is considered the other public health problem around the world. Some studies suggest involving insufficient or deficiency of vitamin Din the etiopathogenesis of T2DM. Materials and methods. 58 patients, 33 women (56.89%) and 25 men (43.10%) were included in the observational study. Demographics (age, gender), personal anamnestic data (duration of diabetes, micro-and macrovascular complications, therapy with vitamin D supplements), anthropometric and biochemical parameters were assessed. The anthropometric measurement included height (meters), weight (kg) and body mass index (BMI) defined as a ratio of weight to the square of height (kg/m2). Biochemical parameters included the fasting blood glucose, glycated hemoglobin (HbA1c), serum total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, very-low density lipoprotein (VLDL) cholesterol, triglycerides (TG), as well the level 25(OH)D. We followed the correlation between vitamin D levels and the duration of diabetes, BMI, blood glucose levels, HbA1c, TC, LDL-cholesterol, HDL-cholesterol, VLDL-cholesterol, TG. Results. The average values recorded were 11.72 years for the duration of T2DM, 31.77 kg/m2 for BMI, 169.00 mg/dL for blood glucose levels, 8.01% for HbA1c, 200.40 mg/dL for TC, 129.04 mg/dL for LDL-cholesterol, 47.67 mg/dL for HDL-cholesterol, 26.69 mg/dL for VLDL-cholesterol and 160.34 mg/dL for TG. Conclusion. Following statistical analysis, the observational study highlight statistically negative correlation recorded between the level of vitamin D and BMI, glycemic balance (highlighted by the level of fasting blood glucose and HbA1c). The results found nonsignificant correlation between the levels of vitamin D: duration of diabetes and lipid profile.

Keywords

• type 2 diabetes mellitus
• insufficient or deficiency of vitamin d
• metabolic consequences