Nature Communications (Jan 2016)

F-actin mechanics control spindle centring in the mouse zygote

  • Agathe Chaigne,
  • Clément Campillo,
  • Raphaël Voituriez,
  • Nir S. Gov,
  • Cécile Sykes,
  • Marie-Hélène Verlhac,
  • Marie-Emilie Terret

DOI
https://doi.org/10.1038/ncomms10253
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

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How the mitotic spindle is positioned in the centre of the cell during the first mitotic division is not clear. Here Chaigne et al.show that the pronucleus coarsely centres using F-actin/Myosin-Vb dynamics, and the metaphase plate is finely centred by an F-actin cage influenced by high cortical tension.