Association of the novel cardiovascular risk factors paraoxonase 1 and cystatin C in type 2 diabetes*[S]

Philip W. Connelly; Bernard Zinman; Graham F. Maguire; Mary Mamakeesick; Stewart B. Harris; Robert A. Hegele; Ravi Retnakaran; Anthony J.G. Hanley

Journal of Lipid Research (Jun 2009)

Association of the novel cardiovascular risk factors paraoxonase 1 and cystatin C in type 2 diabetes*[S]

Philip W. Connelly,
Bernard Zinman,
Graham F. Maguire,
Mary Mamakeesick,
Stewart B. Harris,
Robert A. Hegele,
Ravi Retnakaran,
Anthony J.G. Hanley

Affiliations

Philip W. Connelly: Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Canada; Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital and Department of Medicine, University of Toronto, Toronto, Canada; Sandy Lake Health and Diabetes Project, Sandy Lake First Nation, Ontario, Canada; Centre for Studies in Family Medicine, University of Western Ontario, London, Ontario, Canada; Robarts Research Institute, University of Western Ontario, London, Ontario, Canada; Department of Nutritional Sciences, University of Toronto, Toronto, Canada
Bernard Zinman: Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Canada; Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital and Department of Medicine, University of Toronto, Toronto, Canada; Sandy Lake Health and Diabetes Project, Sandy Lake First Nation, Ontario, Canada; Centre for Studies in Family Medicine, University of Western Ontario, London, Ontario, Canada; Robarts Research Institute, University of Western Ontario, London, Ontario, Canada; Department of Nutritional Sciences, University of Toronto, Toronto, Canada
Graham F. Maguire: Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Canada; Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital and Department of Medicine, University of Toronto, Toronto, Canada; Sandy Lake Health and Diabetes Project, Sandy Lake First Nation, Ontario, Canada; Centre for Studies in Family Medicine, University of Western Ontario, London, Ontario, Canada; Robarts Research Institute, University of Western Ontario, London, Ontario, Canada; Department of Nutritional Sciences, University of Toronto, Toronto, Canada
Mary Mamakeesick: Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Canada; Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital and Department of Medicine, University of Toronto, Toronto, Canada; Sandy Lake Health and Diabetes Project, Sandy Lake First Nation, Ontario, Canada; Centre for Studies in Family Medicine, University of Western Ontario, London, Ontario, Canada; Robarts Research Institute, University of Western Ontario, London, Ontario, Canada; Department of Nutritional Sciences, University of Toronto, Toronto, Canada
Stewart B. Harris: Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Canada; Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital and Department of Medicine, University of Toronto, Toronto, Canada; Sandy Lake Health and Diabetes Project, Sandy Lake First Nation, Ontario, Canada; Centre for Studies in Family Medicine, University of Western Ontario, London, Ontario, Canada; Robarts Research Institute, University of Western Ontario, London, Ontario, Canada; Department of Nutritional Sciences, University of Toronto, Toronto, Canada
Robert A. Hegele: Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Canada; Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital and Department of Medicine, University of Toronto, Toronto, Canada; Sandy Lake Health and Diabetes Project, Sandy Lake First Nation, Ontario, Canada; Centre for Studies in Family Medicine, University of Western Ontario, London, Ontario, Canada; Robarts Research Institute, University of Western Ontario, London, Ontario, Canada; Department of Nutritional Sciences, University of Toronto, Toronto, Canada
Ravi Retnakaran: Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Canada; Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital and Department of Medicine, University of Toronto, Toronto, Canada; Sandy Lake Health and Diabetes Project, Sandy Lake First Nation, Ontario, Canada; Centre for Studies in Family Medicine, University of Western Ontario, London, Ontario, Canada; Robarts Research Institute, University of Western Ontario, London, Ontario, Canada; Department of Nutritional Sciences, University of Toronto, Toronto, Canada
Anthony J.G. Hanley: Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Canada; Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital and Department of Medicine, University of Toronto, Toronto, Canada; Sandy Lake Health and Diabetes Project, Sandy Lake First Nation, Ontario, Canada; Centre for Studies in Family Medicine, University of Western Ontario, London, Ontario, Canada; Robarts Research Institute, University of Western Ontario, London, Ontario, Canada; Department of Nutritional Sciences, University of Toronto, Toronto, Canada

Journal volume & issue: Vol. 50, no. 6
pp. 1216 – 1222

Abstract

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Paraoxonase 1 (PON1) has been reported to be associated with proteinuria in subjects with type 2 diabetes mellitus (T2DM). Plasma cystatin C is more accurate than creatinine for identifying stage 3 kidney disease in T2DM. We tested the hypothesis that PON1 and cystatin C would be associated in T2DM subjects from an Aboriginal Canadian community, who are at high risk for the development of nephropathy. PON1 A(-162)G and PON2 Ala148Gly genotypes, cystatin C, HbA1c, high density lipoprotein cholesterol (HDLC), waist circumference (waist), and duration of diabetes were included in the regression analysis with loge (ln) of PON1 mass as the dependent variable. A regression model including PON2 Ala148Gly genotype, HDLC, and ln cystatin C explained 25.8% of the variance in PON1 mass. Conversely, waist, age, ln HbA1c, ln duration of diabetes, and ln PON1 mass, but not PON2 genotype, explained 38% of the variance in cystatin C. Subjects with cystatin C estimated glomerular filtration rate (eGFR) 60 ml/min per 1.73 m2. The lower mass of PON1, an anti-inflammatory HDL-associated enzyme, in T2DM with cystatin C-eGFR <60 ml/min per 1.73 m2 may contribute to their increased risk for cardiovascular disease.

Published in Journal of Lipid Research

ISSN: 0022-2275 (Print); 1539-7262 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.journals.elsevier.com/journal-of-lipid-research

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