Obesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia

Miyoung Lee; Jamie A. G. Hamilton; Ganesh R. Talekar; Anthony J. Ross; Langston Michael; Manali Rupji; Bhakti Dwivedi; Sunil S. Raikar; Jeremy Boss; Christopher D. Scharer; Douglas K. Graham; Deborah DeRyckere; Christopher C. Porter; Curtis J. Henry

doi:10.1038/s41467-022-28839-y

Nature Communications (Mar 2022)

Obesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia

Miyoung Lee,
Jamie A. G. Hamilton,
Ganesh R. Talekar,
Anthony J. Ross,
Langston Michael,
Manali Rupji,
Bhakti Dwivedi,
Sunil S. Raikar,
Jeremy Boss,
Christopher D. Scharer,
Douglas K. Graham,
Deborah DeRyckere,
Christopher C. Porter,
Curtis J. Henry

Affiliations

Miyoung Lee: Department of Pediatrics, Emory University School of Medicine and Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta
Jamie A. G. Hamilton: Department of Pediatrics, Emory University School of Medicine and Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta
Ganesh R. Talekar: Department of Pediatrics, Emory University School of Medicine and Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta
Anthony J. Ross: Riley Pediatric Cancer and Blood Diseases, Riley Children’s Health, Indiana University School of Medicine, Indianapolis
Langston Michael: Wake Forest University
Manali Rupji: Bioinformatics and Biostatistics Shared Resource, Winship Cancer Institute
Bhakti Dwivedi: Bioinformatics and Biostatistics Shared Resource, Winship Cancer Institute
Sunil S. Raikar: Department of Pediatrics, Emory University School of Medicine and Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta
Jeremy Boss: Department of Microbiology and Immunology, Emory University School of Medicine
Christopher D. Scharer: Department of Microbiology and Immunology, Emory University School of Medicine
Douglas K. Graham: Department of Pediatrics, Emory University School of Medicine and Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta
Deborah DeRyckere: Department of Pediatrics, Emory University School of Medicine and Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta
Christopher C. Porter: Department of Pediatrics, Emory University School of Medicine and Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta
Curtis J. Henry: Department of Pediatrics, Emory University School of Medicine and Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta

DOI: https://doi.org/10.1038/s41467-022-28839-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Obesity has been reported to promote tumourigenesis and chemoresistance but the underlying mechanisms are not completely understood. Here, the authors show that adipocytes induce Galectin-9 (GAL-9) expression in B-acute lymphoblastic leukaemia (B-ALL) cells which leads to chemoresistance and antibody-mediated blockade of GAL-9 increases survival in preclinical B-ALL murine models.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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