Nature Communications (Jun 2021)

Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist

  • Bingfa Sun,
  • Dan Feng,
  • Matthew Ling-Hon Chu,
  • Inbar Fish,
  • Silvia Lovera,
  • Zara A. Sands,
  • Sebastian Kelm,
  • Anne Valade,
  • Martyn Wood,
  • Tom Ceska,
  • Tong Sun Kobilka,
  • Florence Lebon,
  • Brian K. Kobilka

DOI
https://doi.org/10.1038/s41467-021-23519-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

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Recently, a class of non-catechol Dopamine D1 receptor (D1R) selective agonists with novel scaffold and improved pharmacological properties were reported. Here, authors report the crystal structure of D1R in complex with stimulatory G protein (Gs) and a non-catechol agonist Compound 1 which explains the selectivity of this scaffold for D1R over other aminergic receptors and the mechanism of activating D1R.