Emerging Microfluidic Approaches for Platelet Mechanobiology and Interplay With Circulatory Systems

Yingqi Zhang; Yingqi Zhang; Yingqi Zhang; Savindi De Zoysa Ramasundara; Savindi De Zoysa Ramasundara; Savindi De Zoysa Ramasundara; Renee Ellen Preketes-tardiani; Renee Ellen Preketes-tardiani; Renee Ellen Preketes-tardiani; Vivian Cheng; Hongxu Lu; Hongxu Lu; Lining Arnold Ju; Lining Arnold Ju; Lining Arnold Ju

doi:10.3389/fcvm.2021.766513

Frontiers in Cardiovascular Medicine (Nov 2021)

Emerging Microfluidic Approaches for Platelet Mechanobiology and Interplay With Circulatory Systems

Yingqi Zhang,
Yingqi Zhang,
Yingqi Zhang,
Savindi De Zoysa Ramasundara,
Savindi De Zoysa Ramasundara,
Savindi De Zoysa Ramasundara,
Renee Ellen Preketes-tardiani,
Renee Ellen Preketes-tardiani,
Renee Ellen Preketes-tardiani,
Vivian Cheng,
Hongxu Lu,
Hongxu Lu,
Lining Arnold Ju,
Lining Arnold Ju,
Lining Arnold Ju

Affiliations

Yingqi Zhang: School of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Darlington, NSW, Australia
Yingqi Zhang: Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia
Yingqi Zhang: Heart Research Institute, Newtown, NSW, Australia
Savindi De Zoysa Ramasundara: Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia
Savindi De Zoysa Ramasundara: Heart Research Institute, Newtown, NSW, Australia
Savindi De Zoysa Ramasundara: School of Medicine, The University of Notre Dame Sydney, Darlinghurst, NSW, Australia
Renee Ellen Preketes-tardiani: School of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Darlington, NSW, Australia
Renee Ellen Preketes-tardiani: Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia
Renee Ellen Preketes-tardiani: Heart Research Institute, Newtown, NSW, Australia
Vivian Cheng: School of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Darlington, NSW, Australia
Hongxu Lu: School of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Darlington, NSW, Australia
Hongxu Lu: Faculty of Science, Institute for Biomedical Materials and Devices, The University of Technology Sydney, Ultimo, NSW, Australia
Lining Arnold Ju: School of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Darlington, NSW, Australia
Lining Arnold Ju: Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia
Lining Arnold Ju: Heart Research Institute, Newtown, NSW, Australia

DOI: https://doi.org/10.3389/fcvm.2021.766513
Journal volume & issue: Vol. 8

Abstract

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Understanding how platelets can sense and respond to hemodynamic forces in disturbed blood flow and complexed vasculature is crucial to the development of more effective and safer antithrombotic therapeutics. By incorporating diverse structural and functional designs, microfluidic technologies have emerged to mimic microvascular anatomies and hemodynamic microenvironments, which open the floodgates for fascinating platelet mechanobiology investigations. The latest endothelialized microfluidics can even recapitulate the crosstalk between platelets and the circulatory system, including the vessel walls and plasma proteins such as von Willebrand factor. Hereby, we highlight these exciting microfluidic applications to platelet mechanobiology and platelet–circulatory system interplay as implicated in thrombosis. Last but not least, we discuss the need for microfluidic standardization and summarize the commercially available microfluidic platforms for researchers to obtain reproducible and consistent results in the field.

Published in Frontiers in Cardiovascular Medicine

ISSN: 2297-055X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.frontiersin.org/journals/cardiovascular-medicine

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