Вопросы вирусологии (Aug 2015)

Efficacy of polyprenyl phosphates in the experimental genital herpes model

  • A. N. Narovlyansky,
  • А. M. Ivanova,
  • N. V. Shevlyagina,
  • L. V. Didenko,
  • Т. G. Borovaya,
  • А. V. Izmest’eva,
  • А. V. Sanin,
  • А. V. Pronin,
  • F. I. Ershov

Journal volume & issue
Vol. 60, no. 4
pp. 9 – 13

Abstract

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An experimental model of the primary genital herpes (herpes simplex type 2, HSV-2) in the female guinea pigs was suggested to study the infectious process activity of polyprenyl phosphates (PPP) and PPP+acyclovir (AC) complex treatment. The morphofunctional features of the guinea pig ovaries were studied in the control and experimental groups (the latter were inoculated with PPP and/or AC as a primary infection treatment) at the stage of the recurrent genital herpes aggravation. It was shown that in the case of combined PPP +AC use significant changes in the disease symptoms were observed, as well as a decrease in the infectious process activity and duration, and positive remote effect on the ovarian morphophysiology.

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