Case report: A rare case of TBL1XR1-RARB positive acute promyelocytic leukemia in child and review of the literature

Mingyan Jiang; Mingyan Jiang; Jinrong Li; Jinrong Li; Jianrong Wu; Jianrong Wu; Yiping Zhu; Yiping Zhu; Ju Gao; Ju Gao

doi:10.3389/fonc.2022.1028089

Frontiers in Oncology (Nov 2022)

Case report: A rare case of TBL1XR1-RARB positive acute promyelocytic leukemia in child and review of the literature

Mingyan Jiang,
Mingyan Jiang,
Jinrong Li,
Jinrong Li,
Jianrong Wu,
Jianrong Wu,
Yiping Zhu,
Yiping Zhu,
Ju Gao,
Ju Gao

Affiliations

Mingyan Jiang: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
Mingyan Jiang: Key Laboratory Of Birth Defects And Related Diseases Of Women And Children (Sichuan University), Ministry Of Education, Chengdu, China
Jinrong Li: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
Jinrong Li: Key Laboratory Of Birth Defects And Related Diseases Of Women And Children (Sichuan University), Ministry Of Education, Chengdu, China
Jianrong Wu: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
Jianrong Wu: Key Laboratory Of Birth Defects And Related Diseases Of Women And Children (Sichuan University), Ministry Of Education, Chengdu, China
Yiping Zhu: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
Yiping Zhu: Key Laboratory Of Birth Defects And Related Diseases Of Women And Children (Sichuan University), Ministry Of Education, Chengdu, China
Ju Gao: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
Ju Gao: Key Laboratory Of Birth Defects And Related Diseases Of Women And Children (Sichuan University), Ministry Of Education, Chengdu, China

DOI: https://doi.org/10.3389/fonc.2022.1028089
Journal volume & issue: Vol. 12

Abstract

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Some forms of acute myelogenous leukemia (AML) share typical morphological and immunophenotypic features of acute promyelocytic leukemia (APL) but are negative for promyelocytic leukemia-retinoic acid receptor alpha (PML-RARA) fusion. These forms of AML are known as variant APL. Some variants of APL present with retinoic acid receptor beta (RARB) fused or rearranged with partner genes. RARB-positive APL is very rare, resistant to all-trans retinoic acid (ATRA), and associated with poor prognosis. Here, we reported one case with TBL1XR1-RARB positive APL, featured by early onset and no apparent bleeding tendency or coagulation dysfunction. This patient was resistant to ATRA and arsenic trioxide (ATO), but was good responsive to conventional chemotherapy for AML. The case report was followed by a literature review.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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