Detecting topological variations of DNA at single-molecule level

Ke Liu; Chao Pan; Alexandre Kuhn; Adrian Pascal Nievergelt; Georg E. Fantner; Olgica Milenkovic; Aleksandra Radenovic

doi:10.1038/s41467-018-07924-1

Nature Communications (Jan 2019)

Detecting topological variations of DNA at single-molecule level

Ke Liu,
Chao Pan,
Alexandre Kuhn,
Adrian Pascal Nievergelt,
Georg E. Fantner,
Olgica Milenkovic,
Aleksandra Radenovic

Affiliations

Ke Liu: Laboratory of Nanoscale Biology, Institute of Bioengineering, School of Medicine, EPFL
Chao Pan: Electrical and Computer Engineering, University of Illinois at Urbana-Champaign
Alexandre Kuhn: Laboratory of Molecular Biotechnology, Institute of Biotechnology, University of Lausanne
Adrian Pascal Nievergelt: Laboratory for Bio- and Nano-Instrumentation, Institute of Bioengineering and Institute of Microengineering, School of Engineering, EPFL
Georg E. Fantner: Laboratory for Bio- and Nano-Instrumentation, Institute of Bioengineering and Institute of Microengineering, School of Engineering, EPFL
Olgica Milenkovic: Electrical and Computer Engineering, University of Illinois at Urbana-Champaign
Aleksandra Radenovic: Laboratory of Nanoscale Biology, Institute of Bioengineering, School of Medicine, EPFL

DOI: https://doi.org/10.1038/s41467-018-07924-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 9

Abstract

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Ultrathin nanopore membranes have the potential for detecting topological variation in DNA. Here the authors use barcoded DNA to characterise the translocation profiles of DNA with single strand gaps.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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