Revisiting an IgG Fc Loss-of-Function Experiment: the Role of Complement in HIV Broadly Neutralizing Antibody b12 Activity

Benjamin S. Goldberg; Chengzi I. Kaku; Jérémy Dufloo; Timothée Bruel; Olivier Schwartz; David A. Spencer; Ann J. Hessell; Margaret E. Ackerman

doi:10.1128/mBio.01743-21

mBio (Oct 2021)

Revisiting an IgG Fc Loss-of-Function Experiment: the Role of Complement in HIV Broadly Neutralizing Antibody b12 Activity

Benjamin S. Goldberg,
Chengzi I. Kaku,
Jérémy Dufloo,
Timothée Bruel,
Olivier Schwartz,
David A. Spencer,
Ann J. Hessell,
Margaret E. Ackerman

Affiliations

Benjamin S. Goldberg: Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA
Chengzi I. Kaku: Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA
Jérémy Dufloo: Virus and Immunity Unit, Department of Virology, Institut Pasteur, Paris, France
Timothée Bruel: Virus and Immunity Unit, Department of Virology, Institut Pasteur, Paris, France
Olivier Schwartz: Virus and Immunity Unit, Department of Virology, Institut Pasteur, Paris, France
David A. Spencer: Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA
Ann J. Hessell: Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA
Margaret E. Ackerman: ORCiD; Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA

DOI: https://doi.org/10.1128/mBio.01743-21
Journal volume & issue: Vol. 12, no. 5

Abstract

Read online

Given the suboptimal outcome of VRC01 antibody-mediated prevention of HIV-1 infection in its first field trial, means to improve diverse antiviral activities in vivo

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal