PLoS ONE (Jan 2021)

Biomarkers of neurodegeneration and glial activation validated in Alzheimer's disease assessed in longitudinal cerebrospinal fluid samples of Parkinson's disease.

  • Michael Bartl,
  • Mohammed Dakna,
  • Douglas Galasko,
  • Samantha J Hutten,
  • Tatiana Foroud,
  • Marian Quan,
  • Kenneth Marek,
  • Andrew Siderowf,
  • Jonas Franz,
  • Claudia Trenkwalder,
  • Brit Mollenhauer,
  • Parkinson’s Progression Markers Initiative

DOI
https://doi.org/10.1371/journal.pone.0257372
Journal volume & issue
Vol. 16, no. 10
p. e0257372

Abstract

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AimSeveral pathophysiological processes are involved in Parkinson's disease (PD) and could inform in vivo biomarkers. We assessed an established biomarker panel, validated in Alzheimer's Disease, in a PD cohort.MethodsLongitudinal cerebrospinal fluid (CSF) samples from PPMI (252 PD, 115 healthy controls, HC) were analyzed at six timepoints (baseline, 6, 12, 24, 36, and 48 months follow-up) using Elecsys® electrochemiluminescence immunoassays to quantify neurofilament light chain (NfL), soluble TREM2 receptor (sTREM2), chitinase-3-like protein 1 (YKL40), glial fibrillary acidic protein (GFAP), interleukin-6 (IL-6), S100, and total α-synuclein (αSyn).ResultsαSyn was significantly lower in PD (mean 103 pg/ml vs. HC: 127 pg/ml, p0.05) and none showed a significant difference longitudinally. We found significantly higher levels of all these markers between PD patients who developed cognitive decline during follow-up, except for αSyn and IL-6.ConclusionExcept for αSyn, the additional biomarkers did not differentiate PD and HC, and none showed longitudinal differences, but most markers predict cognitive decline in PD during follow-up.