Nature Communications (Nov 2018)

Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis

  • Jared M. Churko,
  • Priyanka Garg,
  • Barbara Treutlein,
  • Meenakshi Venkatasubramanian,
  • Haodi Wu,
  • Jaecheol Lee,
  • Quinton N. Wessells,
  • Shih-Yu Chen,
  • Wen-Yi Chen,
  • Kashish Chetal,
  • Gary Mantalas,
  • Norma Neff,
  • Eric Jabart,
  • Arun Sharma,
  • Garry P. Nolan,
  • Nathan Salomonis,
  • Joseph C. Wu

DOI
https://doi.org/10.1038/s41467-018-07333-4
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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Human induced pluripotent stem cell derived cardiomyocytes are a powerful model for cardiogenesis and disease in vitro. Here the authors comprehensively map cardiac differentiation using multiple modalities, including single-cell RNA seq and CyTOF, in cells with a gain or loss of function in key cardiac transcription factors.