Nature Communications (Aug 2017)
VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis
- Jiahuan Chen,
- Yi Fu,
- Daniel S. Day,
- Ye Sun,
- Shiyan Wang,
- Xiaodong Liang,
- Fei Gu,
- Fang Zhang,
- Sean M. Stevens,
- Pingzhu Zhou,
- Kai Li,
- Yan Zhang,
- Ruei-zeng Lin,
- Lois E. H. Smith,
- Jin Zhang,
- Kun Sun,
- Juan M. Melero-Martin,
- Zeguang Han,
- Peter J. Park,
- Bing Zhang,
- William T. Pu
Affiliations
- Jiahuan Chen
- Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
- Yi Fu
- Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
- Daniel S. Day
- Department for Biomedical Informatics, Harvard Medical School
- Ye Sun
- Department of Ophthalmology, Harvard Medical School/Children’s Hospital Boston
- Shiyan Wang
- Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
- Xiaodong Liang
- Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
- Fei Gu
- Department of Cardiology, Boston Children’s Hospital
- Fang Zhang
- Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
- Sean M. Stevens
- Department of Cardiology, Boston Children’s Hospital
- Pingzhu Zhou
- Department of Cardiology, Boston Children’s Hospital
- Kai Li
- Department of Cardiology, Boston Children’s Hospital
- Yan Zhang
- Renji-Med Clinical Stem Cell Research Center, Renji Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University
- Ruei-zeng Lin
- Department of Cardiac Surgery, Children’s Hospital Boston
- Lois E. H. Smith
- Department of Ophthalmology, Harvard Medical School/Children’s Hospital Boston
- Jin Zhang
- Department of Cardiology, Boston Children’s Hospital
- Kun Sun
- Department of Pediatric Cardiology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
- Juan M. Melero-Martin
- Department of Cardiac Surgery, Children’s Hospital Boston
- Zeguang Han
- Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
- Peter J. Park
- Department for Biomedical Informatics, Harvard Medical School
- Bing Zhang
- Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
- William T. Pu
- Department of Cardiology, Boston Children’s Hospital
- DOI
- https://doi.org/10.1038/s41467-017-00405-x
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Promoter proximal RNAPII pausing is a rate-limiting transcriptional mechanism. Chen et al. show that this process is essential in angiogenesis by demonstrating that the endothelial master transcription factor ETS1 promotes global RNAPII pause release, and that this process is governed by VEGF.
