Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing
Xushan Chen,
Huimin Zhang,
Xin Yang,
Wuhong Zhang,
Ming Jiang,
Ting Wen,
Jie Wang,
Rui Guo,
Hanjiao Liu
Affiliations
Xushan Chen
Shenzhen Bao’an Traditional Chinese Medicine Hospital Group, Shenzhen 518133, China
Huimin Zhang
Shenzhen Bao’an Traditional Chinese Medicine Hospital Group, Shenzhen 518133, China
Xin Yang
Shenzhen Bao’an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen 518033, China
Wuhong Zhang
Shenzhen Bao’an Traditional Chinese Medicine Hospital Group, Shenzhen 518133, China
Ming Jiang
Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Engineering and Technological Research Centre for Drug Carrier Development, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China
Ting Wen
Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
Jie Wang
Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
Rui Guo
Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Engineering and Technological Research Centre for Drug Carrier Development, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China
Hanjiao Liu
Shenzhen Bao’an Traditional Chinese Medicine Hospital Group, Shenzhen 518133, China
Infection is the major reason that people die from burns; however, traditional medical dressings such as gauze cannot restrain bacterial growth and enhance the healing process. Herein, an organic- and inorganic-base hydrogel with antibacterial activities was designed and prepared to treat burn wounds. Oxidized dextran (ODex) and adipic dihydrazide grafted hyaluronic acid (HA-ADH) were prepared, mixed with quaternized chitosan (HACC) and silver nanoparticles to fabricate Ag@ODex/HA-ADH/HACC hydrogel. The hydrogel, composed of nature biomaterials, has a good cytocompatibility and biodegradability. Moreover, the hydrogel has an excellent antibacterial ability and presents fast healing for burn wounds compared with commercial Ag dressings. The Ag@ODex/HA-ADH/HACC hydrogel will be a promising wound dressing to repair burn wounds and will significantly decrease the possibility of bacterial infection.
