Nature Communications (Jun 2019)
Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases
- Akul Singhania,
- Christine M. Graham,
- Leona Gabryšová,
- Lúcia Moreira-Teixeira,
- Evangelos Stavropoulos,
- Jonathan M. Pitt,
- Probir Chakravarty,
- Annika Warnatsch,
- William J. Branchett,
- Laura Conejero,
- Jing-Wen Lin,
- Sophia Davidson,
- Mark S. Wilson,
- Gregory Bancroft,
- Jean Langhorne,
- Eva Frickel,
- Abdul K. Sesay,
- Simon L. Priestnall,
- Eleanor Herbert,
- Marianna Ioannou,
- Qian Wang,
- Ian R. Humphreys,
- Jonathan Dodd,
- Peter J. M. Openshaw,
- Katrin D. Mayer-Barber,
- Dragana Jankovic,
- Alan Sher,
- Clare M. Lloyd,
- Nicole Baldwin,
- Damien Chaussabel,
- Venizelos Papayannopoulos,
- Andreas Wack,
- Jacques F. Banchereau,
- Virginia M. Pascual,
- Anne O’Garra
Affiliations
- Akul Singhania
- Laboratory of Immunoregulation and Infection, The Francis Crick Institute
- Christine M. Graham
- Laboratory of Immunoregulation and Infection, The Francis Crick Institute
- Leona Gabryšová
- Laboratory of Immunoregulation and Infection, The Francis Crick Institute
- Lúcia Moreira-Teixeira
- Laboratory of Immunoregulation and Infection, The Francis Crick Institute
- Evangelos Stavropoulos
- Laboratory of Immunoregulation and Infection, The Francis Crick Institute
- Jonathan M. Pitt
- Laboratory of Immunoregulation and Infection, The Francis Crick Institute
- Probir Chakravarty
- Bioinformatics Core, The Francis Crick Institute
- Annika Warnatsch
- Antimicrobial Defence Laboratory, The Francis Crick Institute
- William J. Branchett
- Inflammation, Repair and Development Section, National Heart and Lung Institute, Imperial College London
- Laura Conejero
- London School of Hygiene and Tropical Medicine
- Jing-Wen Lin
- Malaria Laboratory, The Francis Crick Institute
- Sophia Davidson
- Immunoregulation Laboratory, The Francis Crick Institute
- Mark S. Wilson
- Helminth Immunology Laboratory, The Francis Crick Institute
- Gregory Bancroft
- London School of Hygiene and Tropical Medicine
- Jean Langhorne
- Malaria Laboratory, The Francis Crick Institute
- Eva Frickel
- Host-Toxoplasma Interaction Laboratory, The Francis Crick Institute
- Abdul K. Sesay
- Advanced Sequencing Facility, The Francis Crick Institute
- Simon L. Priestnall
- Department of Pathobiology & Population Sciences, Royal Veterinary College
- Eleanor Herbert
- Department of Pathobiology & Population Sciences, Royal Veterinary College
- Marianna Ioannou
- Antimicrobial Defence Laboratory, The Francis Crick Institute
- Qian Wang
- Antimicrobial Defence Laboratory, The Francis Crick Institute
- Ian R. Humphreys
- Division of Infection and Immunity/Systems Immunity University Research Institute, Cardiff University
- Jonathan Dodd
- Respiratory Infection Section, National Heart and Lung Institute, Imperial College London
- Peter J. M. Openshaw
- Respiratory Infection Section, National Heart and Lung Institute, Imperial College London
- Katrin D. Mayer-Barber
- Inflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Dragana Jankovic
- Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Alan Sher
- Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Clare M. Lloyd
- Inflammation, Repair and Development Section, National Heart and Lung Institute, Imperial College London
- Nicole Baldwin
- Baylor Institute for Immunology Research
- Damien Chaussabel
- Systems Biology and Immunology Department, Sidra Medicine
- Venizelos Papayannopoulos
- Antimicrobial Defence Laboratory, The Francis Crick Institute
- Andreas Wack
- Immunoregulation Laboratory, The Francis Crick Institute
- Jacques F. Banchereau
- The Jackson Laboratory for Genomic Medicine
- Virginia M. Pascual
- Drukier Institute for Children’s Health, Weill Cornell Medical College
- Anne O’Garra
- Laboratory of Immunoregulation and Infection, The Francis Crick Institute
- DOI
- https://doi.org/10.1038/s41467-019-10601-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 21
Abstract
The authors present an extensive profile of host transcriptional respones to a diverse group of pathogens and allergens. In doing so, they identify TH1, type I IFN, TH17, and TH2 responses, that underlie each immune response in both the blood and lung, which represents a global profile of host-pathogen immune responses.
