Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes

Sang H. Lee; Seung Min Shin; Peng Zhong; Hyun-Taek Kim; Dong-Il Kim; June Myoung Kim; Won Do Heo; Dae-Won Kim; Chang-Yeol Yeo; Cheol-Hee Kim; Qing-song Liu

doi:10.1038/s41467-018-05858-2

Nature Communications (Aug 2018)

Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes

Sang H. Lee,
Seung Min Shin,
Peng Zhong,
Hyun-Taek Kim,
Dong-Il Kim,
June Myoung Kim,
Won Do Heo,
Dae-Won Kim,
Chang-Yeol Yeo,
Cheol-Hee Kim,
Qing-song Liu

Affiliations

Sang H. Lee: Department of Pharmacology and Toxicology, Medical College of Wisconsin
Seung Min Shin: Department of Pharmacology and Toxicology, Medical College of Wisconsin
Peng Zhong: Department of Pharmacology and Toxicology, Medical College of Wisconsin
Hyun-Taek Kim: Department of Biology, Chungnam National University
Dong-Il Kim: Department of Pharmacology and Toxicology, Medical College of Wisconsin
June Myoung Kim: Department of Biochemistry, Yonsei University
Won Do Heo: Department of Biological Sciences, Korea Advanced Institute of Science and Technology
Dae-Won Kim: Department of Biochemistry, Yonsei University
Chang-Yeol Yeo: Department of Life Science and Research Center for Cellular Homeostasis, Ewha Woman’s University
Cheol-Hee Kim: Department of Biology, Chungnam National University
Qing-song Liu: Department of Pharmacology and Toxicology, Medical College of Wisconsin

DOI: https://doi.org/10.1038/s41467-018-05858-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

Read online

Wnts are important for synapse formation and maintenance. Here, the authors show that proline-rich 7 (PRR7) is a Wnt inhibitor that is secreted via exosomes to regulate excitatory synapse numbers.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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