Nature Communications (Jun 2019)

Chromosome dynamics near the sol-gel phase transition dictate the timing of remote genomic interactions

  • Nimish Khanna,
  • Yaojun Zhang,
  • Joseph S. Lucas,
  • Olga K. Dudko,
  • Cornelis Murre

DOI
https://doi.org/10.1038/s41467-019-10628-9
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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Antibodies are generated through remote genomic interactions involving immunoglobulin variable (VH), diversity (DH) and joining (JH) gene segments. Here the authors develop a strategy to track VH-DHJH motion in B-lymphocytes and provide evidence that chromosome organisation near the sol-gel phase transition dictates the timing of genomic interactions to orchestrate gene expression and somatic recombination.