Nature Communications (Mar 2019)

Enterovirus particles expel capsid pentamers to enable genome release

  • David Buchta,
  • Tibor Füzik,
  • Dominik Hrebík,
  • Yevgen Levdansky,
  • Lukáš Sukeník,
  • Liya Mukhamedova,
  • Jana Moravcová,
  • Robert Vácha,
  • Pavel Plevka

DOI
https://doi.org/10.1038/s41467-019-09132-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 9

Abstract

Read online

Genome release of enteroviruses relies on exposure to acidic pH, but the mechanism of uncoating remains unclear. Here, Buchta et al. show that echovirus 18 loses one to three adjacent capsid-protein pentamers, resulting in an opening of more than 120 Å for genome release.