Nature Communications (Mar 2022)

Progression of type 1 diabetes from latency to symptomatic disease is predicted by distinct autoimmune trajectories

  • Bum Chul Kwon,
  • Vibha Anand,
  • Peter Achenbach,
  • Jessica L. Dunne,
  • William Hagopian,
  • Jianying Hu,
  • Eileen Koski,
  • Åke Lernmark,
  • Markus Lundgren,
  • Kenney Ng,
  • Jorma Toppari,
  • Riitta Veijola,
  • Brigitte I. Frohnert,
  • the T1DI Study Group

DOI
https://doi.org/10.1038/s41467-022-28909-1
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 9

Abstract

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Presence of islet autoantibodies precedes the onset of type 1 diabetes but it does not predict whether and how fast symptomatic disease appears. Here authors present a model to predict and visualize progression to diabetes by using a large longitudinal data set on autoantibodies and clinical parameters as input.