Nature Communications (Nov 2022)

Smc5/6’s multifaceted DNA binding capacities stabilize branched DNA structures

  • Jeremy T-H. Chang,
  • Shibai Li,
  • Emily C. Beckwitt,
  • Thane Than,
  • Cory Haluska,
  • Joshua Chandanani,
  • Michael E. O’Donnell,
  • Xiaolan Zhao,
  • Shixin Liu

DOI
https://doi.org/10.1038/s41467-022-34928-9
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 11

Abstract

Read online

Using single-molecule visualization and manipulation, Chang et al. show that the eukaryotic Smc5/6 complex preferentially binds to and stabilizes ssDNA-dsDNA junctions, which could serve as the molecular basis for its diverse roles in genome maintenance.