Al Ameen Journal of Medical Sciences (Jan 2011)
Lipid Profile and Serum Paraoxonase1 Activity in CRF Patients Pre and Posthemodialysis
Abstract
Chronic renal failure (CRF) is associated with an increased risk of cardiovascular disease (CVD). In the present study, 30 CRF patients undergoing hemodialysis and 50 healthy controls matching in age and sex were included. We have estimated blood urea, serum creatinine, lipid profile and serum Paraoxonase1 (PON1) activity in pre and post hemodialytic samples. HDL-Cholesterol (HDLC) and serum Paraoxonase1(PON1) activity was found to be significantly reduced (P<0.001) in CRF patients as compared to that of controls. However HDL-Cholesterol (HDLC) and Paraoxonase1 (PON1) show significant elevation (P<0.001) post hemodialysis than prehemodialytic samples of CRF patients. The levels of blood urea, serum creatinine, total cholesterol, LDL-Cholesterol (LDLC) and Triglyceride (TG) were significantly elevated (P<0.001) in CRF patients. After hemodialysis these parameters were significantly reduced (P<0.001) as compared to pre hemodialytic samples. The low HDL-Cholesterol (HDLC) and serum Paraoxonase1 (PON1) activity may be responsible factor for cardiovascular disease associated with CRF. Therefore, management of CRF patients by Hemodialysis (HD) has beneficial effect.
