miR-590–5p: A double-edged sword in the oncogenesis process

Abstract

Accumulating evidence suggests the critical role of miR-590–5p in various aspects of cellular homeostasis, including cancer. Furthermore, we and others have recently demonstrated that miRNA-590–5p acts as an oncogene in some cancers while it acts as a tumor-suppressor in others. However, the role of miR-590–5p in oncogenesis is more complex, like a double-edged sword. Thus, this systematic review introduces the concept, mechanism, and biological function of miR-590–5p to resolve this apparent paradox. We have also described the involvement of miR-590–5p in crucial cancer-hallmarks processes like proliferation, invasion, metastasis, and chemo radioresistance. Finally, we have presented the possible genes/pathways targets of miR-590–5p through bioinformatics analysis. This review may help in designing better biomarkers and therapeutic targets for cancers.

Keywords

• MicroRNA
• miR-590-5p
• Cancer
• Biomarker
• Therapeutic target