Aripiprazole-Induced Oculogyric Crisis: A Pediatric Case Series and A Brief Narrative Review
Pia Bernardo,
Alfonso Rubino,
Claudia Santoro,
Carmela Bravaccio,
Marco Pozzi,
Simone Pisano
Affiliations
Pia Bernardo
Department of Neurosciences, Pediatric Psychiatry and Neurology, Santobono-Pausilipon Children’s Hospital, 80120 Naples, Italy
Alfonso Rubino
Department of Neurosciences, Pediatric Neurology, Santobono-Pausilipon Children’s Hospital, 80129 Naples, Italy
Claudia Santoro
Neurofibromatosis Referral Center, Department of Woman, Child, General and Specialized Surgery, Università degli Studi della Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Carmela Bravaccio
Department of Translational Medical Sciences, Federico II University, 80138 Naples, Italy
Marco Pozzi
Scientific Institute IRCCS Eugenio Medea, 23842 Bosisio Parini, Italy
Simone Pisano
Department of Translational Medical Sciences, Federico II University, 80138 Naples, Italy
Oculogyric crisis (OGC) represent an unusual type of dystonic movement disorder, usually reported as an adverse event of antipsychotic drugs, with acute or tardive onset, likely due to a functional disruption of dopaminergic neurotransmission. It is seldom reported in children with aripiprazole, an atypical antipsychotic commonly used in youths. In this manuscript, we report on a case series of three pediatric patients and provide a brief narrative review of the literature, in order to increase the awareness of clinicians and to foster future research in this area.
