Memorias do Instituto Oswaldo Cruz (Sep 2003)

Antibody isotype responses in Balb/c mice immunized with the cytoplasmic repetitive antigen and flagellar repetitive antigen of Trypanosoma cruzi

  • Valéria RA Pereira,
  • Virginia Maria B Lorena,
  • Alinne Fernanda A Verçosa,
  • Edmilson D Silva,
  • Antonio GP Ferreira,
  • Ulisses R Montarroyos,
  • Ana P Galvão Silva,
  • Yara M Gomes

DOI
https://doi.org/10.1590/S0074-02762003000600019
Journal volume & issue
Vol. 98, no. 6
pp. 823 – 825

Abstract

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In the present report we analyzed the levels of IgG1, IgG2a, IgG2b and IgG3 isotypes from Balb/c mice immunized with cytoplasmic repetitive antigen (CRA), and flagelar repetitive antigen (FRA) of Trypanosoma cruzi. The immunization was done by subcutaneous route three times (20 days apart) and the analysis was performed 14 days after each treatment. CRA-immunized mice produced high levels of all IgG isotypes, mainly IgG3 and IgG1. FRA-immunization elicited only high levels of IgG1.

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