Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors

Abstract

A series of novel quinoline-3-carboxamide derivatives <strong>10</strong>–<strong>17</strong> and <strong>23</strong>–<strong>27</strong> were designed and synthesized as cholesteryl ester transfer protein (CETP) inhibitors. All of them exhibited activity against CETP. Particularly, compounds <strong>24</strong> and <strong>26</strong> displayed the best activity against CETP with the same inhibitory rate of 80.1%.

Keywords

• CETP inhibitors
• CETP
• quinoline-3-carboxamide derivatives
• synthesis
• high density lipoprotein cholesterol