Correction of cardiovascular disorders in diabetic patients with depressive simptoms

Abstract

We studied the influence of mexidol and a-lipoic acid on cardiovascular and affective disorders' severity in patients with diabetes. 14-day administration of mexidol (300 mg/day) and a-lipoic acid (600 mg/day) had a positive impact on depressive guilt dinamics in association with a decrease in QTn-interval duration. Moreover, mexidol decreased patients' propencity to postural hypotension, and alfa-lipoic acid corrected myocardial diastolic function, pulmonary blood flow and circadian glycemia.

Keywords

• diabetes mellitus
• depression
• diastolic myocardial dysfunction
• pulmonary artery pressure
• cardiovascular autonomic dysfunction
• qt-interval
• mexidol
• a-lipoic acid