Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway

Yuta Hatori; Ye Yan; Katharina Schmidt; Eri Furukawa; Nesrin M. Hasan; Nan Yang; Chin-Nung Liu; Shanthini Sockanathan; Svetlana Lutsenko

doi:10.1038/ncomms10640

Nature Communications (Feb 2016)

Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway

Yuta Hatori,
Ye Yan,
Katharina Schmidt,
Eri Furukawa,
Nesrin M. Hasan,
Nan Yang,
Chin-Nung Liu,
Shanthini Sockanathan,
Svetlana Lutsenko

Affiliations

Yuta Hatori: Department of Physiology, Johns Hopkins University, School of Medicine
Ye Yan: Department of Neuroscience, Johns Hopkins University, School of Medicine
Katharina Schmidt: Department of Physiology, Johns Hopkins University, School of Medicine
Eri Furukawa: Department of Physiology, Johns Hopkins University, School of Medicine
Nesrin M. Hasan: Department of Physiology, Johns Hopkins University, School of Medicine
Nan Yang: Department of Physiology, Johns Hopkins University, School of Medicine
Chin-Nung Liu: Department of Physiology, Johns Hopkins University, School of Medicine
Shanthini Sockanathan: Department of Neuroscience, Johns Hopkins University, School of Medicine
Svetlana Lutsenko: Department of Physiology, Johns Hopkins University, School of Medicine

DOI: https://doi.org/10.1038/ncomms10640
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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Differentiating neurons have an increased requirement for copper than their precursors, but the mechanism of altered copper homoeostasis is not known. Here, Hatori et al. show that neuronal differentiation is accompanied by an increased flux of copper through the secretory pathway, increasing supply to copper-dependent enzymes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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