Retrospective analysis of drug eruption in 440 cases

Abstract

Objective: To explore the clinical characteristics and allergenic drugs of drug eruption, providing reference for the diagnosis and the treatment of drug eruption. Methods: We retrospectively analyzed the clinical data of 440 inpatients with drug eruption in the first affiliated hospital of Chongqing medical university from 2013.06-2018.06. Results: Among the 440 patients, allergenic drugs were identified in 283 patients. Antibiotics were the most common drugs (37.10%), followed by Chinese herb medicines and patent medicines (28.62%). Erythema multiforme (29.54%) was the most common in mild to moderate drug eruption, while Stevens-Johnson syndrome (10.91%) was the most common in severe drug eruption. Conclusions: The main allergenic drugs in patients with mild to moderate drug eruption and severe drug eruption are antibiotics, and Chinese herb medicines and patent medicines, respectively. In clinic, drugs, especially antibiotics, should be properly used. Chinese herb medicines and patent medicines should be used according to their indications, avoiding abuse of them.

Keywords

• drug eruption
• antibiotics
• chinese herb medicines and patent medicines