FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans

Hyo Sub Choi; Ajay Bhat; Marshall B. Howington; Megan L. Schaller; Rebecca L. Cox; Shijiao Huang; Safa Beydoun; Hillary A. Miller; Angela M. Tuckowski; Joy Mecano; Elizabeth S. Dean; Lindy Jensen; Daniel A. Beard; Charles R. Evans; Scott F. Leiser

doi:10.1038/s41467-023-36181-0

Nature Communications (Feb 2023)

FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans

Hyo Sub Choi,
Ajay Bhat,
Marshall B. Howington,
Megan L. Schaller,
Rebecca L. Cox,
Shijiao Huang,
Safa Beydoun,
Hillary A. Miller,
Angela M. Tuckowski,
Joy Mecano,
Elizabeth S. Dean,
Lindy Jensen,
Daniel A. Beard,
Charles R. Evans,
Scott F. Leiser

Affiliations

Hyo Sub Choi: Department of Molecular and Integrative Physiology, University of Michigan
Ajay Bhat: Department of Molecular and Integrative Physiology, University of Michigan
Marshall B. Howington: Cellular and Molecular Biology Program, University of Michigan
Megan L. Schaller: Department of Molecular and Integrative Physiology, University of Michigan
Rebecca L. Cox: Department of Molecular and Integrative Physiology, University of Michigan
Shijiao Huang: Department of Molecular and Integrative Physiology, University of Michigan
Safa Beydoun: Department of Molecular and Integrative Physiology, University of Michigan
Hillary A. Miller: Cellular and Molecular Biology Program, University of Michigan
Angela M. Tuckowski: Cellular and Molecular Biology Program, University of Michigan
Joy Mecano: Department of Molecular and Integrative Physiology, University of Michigan
Elizabeth S. Dean: Department of Molecular and Integrative Physiology, University of Michigan
Lindy Jensen: Department of Molecular and Integrative Physiology, University of Michigan
Daniel A. Beard: Department of Molecular and Integrative Physiology, University of Michigan
Charles R. Evans: Department of Internal Medicine, University of Michigan
Scott F. Leiser: Department of Molecular and Integrative Physiology, University of Michigan

DOI: https://doi.org/10.1038/s41467-023-36181-0
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 16

Abstract

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Flavin containing monooxygenase 2 (FMO-2) is known to increase lifespan under dietary restriction through incompletely understood mechanisms. Here the authors report that FMO-2 modifies tryptophan and methionine metabolic pathways to enhance stress resistance and slow aging in C. elegans.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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