Efficiency assessment of probiotics for children on complex therapy of acute respiratory syndrome with gastrointestinal disorder at out-patient’s clinics

Abstract

Background. The combined pathology of acute respiratory syndrome with gastrointestinal disorder is highly relevant. At this moment there were only a few studies for children on the subjects of the role of respiratory viruses and gastrointestinal pathogens with examination the materials (oropharynx and intestines). That’s why the certain role of particular pathogens in their combination are not completely determined.Objectives. The purpose of the study was to determine the role of viruses for children with acute respiratory syndrome with gastrointestinal disorder, depending on age and time of year in the period of COVID-pandemic. To evaluate the efficacy of the popular oral probiotics (oil drops dosage form) based on the results of clinical and laboratory tests in the complex therapy of acute respiratory syndrome with gastrointestinal disorder.Materials and methods. An open prospective observational study was conducted at out-patient’s clinics in the period of COVID-pandemic (04.2022-04.2023) and involved 100 children at the age of 1 month to 18 years. All children were examined on the subject of nucleic acids viruses (multiplex PCR diagnostics) from the oropharynx and feces. Additionally, there were evaluated the efficacy of probiotics. Group 1 (n = 50) received Adiarin® Probio at a dose of 6 drops 1-2 times a day. Group 2 (n = 50) received BioGaia® at a dose of 5 drops 1-2 times a day.Results. The results of the study showed high efficiency and sensitivity of the conducted probiotic therapy. However, for group 1, there was established greater sensitivity in viral infections management based on the test results of pharyngeal and fecal materials. At the same time, the width (95%) confidence interval of the Group 1 was less than for the Group 2, which means greater statistical reliability for the results interpretation.Conclusion. The study revealed differences in the seasonal circulation of viruses ib the period of COVID-pandemic, the change of the main pathogens in the oropharynx and feces. From the point of view of clinical practice, it is worth giving preference to probiotics which let treat patients shorter and need less number of additional medicines, as a result it means less drug and economic overloading for patients.

Keywords

• probiotics adiarin® probio and biogaia®
• combined acute respiratory syndrome with gastrointestinal disorder
• examination
• therapy