PLoS ONE (Jan 2014)

Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries.

  • Naowarat Tanomsing,
  • Mayfong Mayxay,
  • Paul N Newton,
  • Francois Nosten,
  • Christiane Dolecek,
  • Tran Tinh Hien,
  • Nicholas J White,
  • Nicholas P J Day,
  • Arjen M Dondorp,
  • Mallika Imwong

DOI
https://doi.org/10.1371/journal.pone.0093942
Journal volume & issue
Vol. 9, no. 4
p. e93942

Abstract

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The dihydropteroate synthase (dhps) genes of 44 P. malariae strains from four Asian countries were isolated. Only a limited number of polymorphisms were observed. Comparison with homologous mutations in other Plasmodium species showed that these polymorphisms are unlikely to be associated with sulfadoxine resistance.