International Journal of Infectious Diseases (Feb 2022)
Epidemiology of concurrent extrapulmonary tuberculosis in inpatients with extrapulmonary tuberculosis lesions in China: a large-scale observational multi-centre investigation
- Wanli Kang,
- Shengsheng Liu,
- Jian Du,
- Peijun Tang,
- Hongyan Chen,
- Jianxiong Liu,
- Jinshan Ma,
- Mingwu Li,
- Jingmin Qin,
- Wei Shu,
- Peilan Zong,
- Yi Zhang,
- Yongkang Dong,
- Zhiyi Yang,
- Zaoxian Mei,
- Qunyi Deng,
- Pu Wang,
- Wenge Han,
- Xiaofeng Yan,
- Ling Chen,
- Xinguo Zhao,
- Lei Tan,
- Fujian Li,
- Chao Zheng,
- Hongwei Liu,
- Xinjie Li,
- Ertai A,
- Yingrong Du,
- Fenglin Liu,
- Wenyu Cui,
- Quanhong Wang,
- Xiaohong Chen,
- Junfeng Han,
- Qingyao Xie,
- Yanmei Feng,
- Wenyu Liu,
- Song Yang,
- Jianyong Zhang,
- Jian Zheng,
- Dawei Chen,
- Xiangyang Yao,
- Tong Ren,
- Yan Li,
- Yuanyuan Li,
- Lei Wu,
- Qiang Song,
- Xinghua Shen,
- Jian Zhang,
- Yuanyuan Liu,
- Shuliang Guo,
- Kun Yan,
- Mei Yang,
- Dan Lei,
- Yanli Zhang,
- Meiying Wu,
- Liang Li,
- Shenjie Tang
Affiliations
- Wanli Kang
- Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumour Research Institute, Beijing, China
- Shengsheng Liu
- Anhui Chest Hospital, Hefei, Auhui, China
- Jian Du
- Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumour Research Institute, Beijing, China
- Peijun Tang
- The Fifth People's Hospital of Suzhou, Suzhou, Jiangsu, China
- Hongyan Chen
- Shenyang Chest Hospital, Liaoning, Shenyang, China
- Jianxiong Liu
- Guang Zhou Chest Hospital, Guangzhou, Guangdong, China
- Jinshan Ma
- Chest Hospital of Xinjiang, Urumqi, Xinjiang, China
- Mingwu Li
- The Third People's Hospital of Kunming, Kunming, Yunnan, China
- Jingmin Qin
- Shandong Provincial Chest Hospital, Jinan, Shandong, China
- Wei Shu
- Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumour Research Institute, Beijing, China
- Peilan Zong
- Jiangxi Chest Hospital, Nanchang, Jiangxi, China
- Yi Zhang
- Chang Chun Infectious Diseases Hospital, Changchun, Jilin, China
- Yongkang Dong
- Taiyuan Fourth People's Hospital, Taiyuan, Shanxi, China
- Zhiyi Yang
- Fuzhou Pulmonary Hospital of Fujian, Fuzhou, Fujian, China
- Zaoxian Mei
- Tianjin Haihe Hospital, Tianjin, China
- Qunyi Deng
- Third People's Hospital of Shenzhen, Shenzhen, Guangdong, China
- Pu Wang
- The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
- Wenge Han
- Weifang No.2 People's Hospital, Weifang, Shandong, China
- Xiaofeng Yan
- Chongqing Public Health Medical Center, Chongqing, China
- Ling Chen
- Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou, China
- Xinguo Zhao
- The Fifth People's Hospital of Wuxi, Wuxi, Jiangsu, China
- Lei Tan
- TB Hospital of Siping City, Siping, Jilin, China
- Fujian Li
- Baoding Hospital for Infectious Disease, Baoding, Hebei, China
- Chao Zheng
- The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China
- Hongwei Liu
- Shenyang Chest Hospital, Liaoning, Shenyang, China
- Xinjie Li
- Guang Zhou Chest Hospital, Guangzhou, Guangdong, China
- Ertai A
- Chest Hospital of Xinjiang, Urumqi, Xinjiang, China
- Yingrong Du
- The Third People's Hospital of Kunming, Kunming, Yunnan, China
- Fenglin Liu
- Shandong Provincial Chest Hospital, Jinan, Shandong, China
- Wenyu Cui
- Chang Chun Infectious Diseases Hospital, Changchun, Jilin, China
- Quanhong Wang
- Taiyuan Fourth People's Hospital, Taiyuan, Shanxi, China
- Xiaohong Chen
- Fuzhou Pulmonary Hospital of Fujian, Fuzhou, Fujian, China
- Junfeng Han
- Tianjin Haihe Hospital, Tianjin, China
- Qingyao Xie
- Third People's Hospital of Shenzhen, Shenzhen, Guangdong, China
- Yanmei Feng
- The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
- Wenyu Liu
- Weifang No.2 People's Hospital, Weifang, Shandong, China
- Song Yang
- Chongqing Public Health Medical Center, Chongqing, China
- Jianyong Zhang
- Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou, China
- Jian Zheng
- The Fifth People's Hospital of Wuxi, Wuxi, Jiangsu, China
- Dawei Chen
- Baoding Hospital for Infectious Disease, Baoding, Hebei, China
- Xiangyang Yao
- The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China
- Tong Ren
- Shenyang Chest Hospital, Liaoning, Shenyang, China
- Yan Li
- Guang Zhou Chest Hospital, Guangzhou, Guangdong, China
- Yuanyuan Li
- Chest Hospital of Xinjiang, Urumqi, Xinjiang, China
- Lei Wu
- The Third People's Hospital of Kunming, Kunming, Yunnan, China
- Qiang Song
- Shandong Provincial Chest Hospital, Jinan, Shandong, China
- Xinghua Shen
- The Fifth People's Hospital of Suzhou, Suzhou, Jiangsu, China
- Jian Zhang
- Chang Chun Infectious Diseases Hospital, Changchun, Jilin, China
- Yuanyuan Liu
- Tianjin Haihe Hospital, Tianjin, China
- Shuliang Guo
- The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
- Kun Yan
- Weifang No.2 People's Hospital, Weifang, Shandong, China
- Mei Yang
- Chongqing Public Health Medical Center, Chongqing, China
- Dan Lei
- Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou, China
- Yanli Zhang
- Baoding Hospital for Infectious Disease, Baoding, Hebei, China
- Meiying Wu
- The Fifth People's Hospital of Suzhou, Suzhou, Jiangsu, China; Corresponding authors. Addresses: Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China (Shenjie Tang and Liang Li); The Fifth People's Hospital of Suzhou, Jiangsu, China (Meiying Wu).
- Liang Li
- Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumour Research Institute, Beijing, China; Corresponding authors. Addresses: Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China (Shenjie Tang and Liang Li); The Fifth People's Hospital of Suzhou, Jiangsu, China (Meiying Wu).
- Shenjie Tang
- Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumour Research Institute, Beijing, China; Corresponding authors. Addresses: Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China (Shenjie Tang and Liang Li); The Fifth People's Hospital of Suzhou, Jiangsu, China (Meiying Wu).
- Journal volume & issue
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Vol. 115
pp. 79 – 85
Abstract
ABSTRACT: Aims: A high proportion of all patients with tuberculosis (TB) present with extrapulmonary TB (EPTB), including concurrent EPTB involving more than one extrapulmonary lesion site. However, previous reports only characterized lesions of single-site EPTB cases. This study aimed to investigate epidemiological characteristics and association rules of concurrent EPTB cases in China. Methods: An observational multi-centre study of 208,214 patients with EPTB lesions was undertaken in China from January 2011 to December 2017. Multi-variable logistic regression analysis was used to identify associations between gender and concurrent EPTB, and age and concurrent EPTB. Association rules were analysed for significance using the Apriori algorithm. Results: The most common EPTB lesion was tuberculous pleurisy (49.8%), followed by bronchial TB (14.8%) and tuberculous meningitis (7.6%). The most common type of concurrent EPTB was tuberculous pleurisy concurrent with tuberculous peritonitis (1.80%). In total, 22 association rules, including 20 strong association rules, were identified; among these, the highest confidence rates were found for tuberculous myelitis concurrent with tuberculous meningitis, and sacral TB concurrent with lumbar vertebral TB. The association rules of EPTB concurrent with other EPTB types were found to vary with gender and age. The confidence rate of tuberculous myelitis concurrent with tuberculous meningitis was higher in females (83.67%) than males, and was highest in patients aged 25–34 years (87.50%). Conclusions: Many types of concurrent EPTB were found. Greater awareness of concurrent EPTB disease characteristics is needed to ensure timely clinical diagnosis and treatment of this disease.
