Potential of Areca catechu Nut Extract for Osteoarthritis: Study on Rat Model

Abstract

Introduction: Osteoarthritis (OA) is a leading cause of disability among aged people. Commonly used, nonsteroidal anti-inflammatory drugs do not give significant results without side effects. Areca catechu seed has an anti-inflammatory effect. The objective of this research is to evaluate the anti-inflammatory effect of A. catechu extract on rat model of OA. Methods: Research design was posttest only with control groups. Male Sprague Dawley rats weighed 175–200 g and were induced by monosodium iodoacetate to make OA modeling. Rats were randomly divided into four groups, namely Group 1 received 120 mg/200 g BW A. catechu extract, Group 2 received 360 mg/200 g BW A. catechu extract, Group 3 received 0.270 mg/200 g BW meloxicam, and Group 4 received distilled water as a negative control. Treatments were given started 7 days’ postinduction for 28 days. Rats’ knee was measured using micrometer digital. Histopathology assessment using Haematoxylin and Eosin stain. Statistical analysis used one way ANOVA test with a significance level P 0.05). The histopathology of knee join among the treatment’s groups was improved with time. Conclusion: A. catechu has an effect on reducing joint inflammation of the knee after OA induction by monosodium iodoacetate.

Keywords

• areca catechu nut
• betel nut
• inflammation
• osteoarthritis
• monosodium iodoacetate