Nature Communications (Jul 2019)
Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets
- Felicity Newell,
- Yan Kong,
- James S. Wilmott,
- Peter A. Johansson,
- Peter M. Ferguson,
- Chuanliang Cui,
- Zhongwu Li,
- Stephen H. Kazakoff,
- Hazel Burke,
- Tristan J. Dodds,
- Ann-Marie Patch,
- Katia Nones,
- Varsha Tembe,
- Ping Shang,
- Louise van der Weyden,
- Kim Wong,
- Oliver Holmes,
- Serigne Lo,
- Conrad Leonard,
- Scott Wood,
- Qinying Xu,
- Robert V. Rawson,
- Pamela Mukhopadhyay,
- Reinhard Dummer,
- Mitchell P. Levesque,
- Göran Jönsson,
- Xuan Wang,
- Iwei Yeh,
- Hong Wu,
- Nancy Joseph,
- Boris C. Bastian,
- Georgina V. Long,
- Andrew J. Spillane,
- Kerwin F. Shannon,
- John F. Thompson,
- Robyn P. M. Saw,
- David J. Adams,
- Lu Si,
- John V. Pearson,
- Nicholas K. Hayward,
- Nicola Waddell,
- Graham J. Mann,
- Jun Guo,
- Richard A. Scolyer
Affiliations
- Felicity Newell
- QIMR Berghofer Medical Research Institute
- Yan Kong
- Department of Renal Cancer and Melanoma, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Cancer Hospital & Institute
- James S. Wilmott
- Melanoma Institute Australia, The University of Sydney
- Peter A. Johansson
- QIMR Berghofer Medical Research Institute
- Peter M. Ferguson
- Melanoma Institute Australia, The University of Sydney
- Chuanliang Cui
- Department of Renal Cancer and Melanoma, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Cancer Hospital & Institute
- Zhongwu Li
- Department of Renal Cancer and Melanoma, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Cancer Hospital & Institute
- Stephen H. Kazakoff
- QIMR Berghofer Medical Research Institute
- Hazel Burke
- Sydney Medical School, The University of Sydney
- Tristan J. Dodds
- Melanoma Institute Australia, The University of Sydney
- Ann-Marie Patch
- QIMR Berghofer Medical Research Institute
- Katia Nones
- QIMR Berghofer Medical Research Institute
- Varsha Tembe
- Centre for Cancer Research, Westmead Institute for Medical Research, The University of Sydney
- Ping Shang
- Sydney Medical School, The University of Sydney
- Louise van der Weyden
- Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton
- Kim Wong
- Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton
- Oliver Holmes
- QIMR Berghofer Medical Research Institute
- Serigne Lo
- Melanoma Institute Australia, The University of Sydney
- Conrad Leonard
- QIMR Berghofer Medical Research Institute
- Scott Wood
- QIMR Berghofer Medical Research Institute
- Qinying Xu
- QIMR Berghofer Medical Research Institute
- Robert V. Rawson
- Melanoma Institute Australia, The University of Sydney
- Pamela Mukhopadhyay
- QIMR Berghofer Medical Research Institute
- Reinhard Dummer
- Dermatology Clinic, University Hospital Zürich, University of Zurich
- Mitchell P. Levesque
- Dermatology Clinic, University Hospital Zürich, University of Zurich
- Göran Jönsson
- Department of Oncology, Clinical Sciences, Lund University
- Xuan Wang
- Department of Renal Cancer and Melanoma, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Cancer Hospital & Institute
- Iwei Yeh
- Departments of Dermatology and Pathology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF)
- Hong Wu
- Department of Pathology, Fox Chase Cancer Center
- Nancy Joseph
- Department of Pathology, University of California
- Boris C. Bastian
- Departments of Dermatology and Pathology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF)
- Georgina V. Long
- Melanoma Institute Australia, The University of Sydney
- Andrew J. Spillane
- Melanoma Institute Australia, The University of Sydney
- Kerwin F. Shannon
- Melanoma Institute Australia, The University of Sydney
- John F. Thompson
- Melanoma Institute Australia, The University of Sydney
- Robyn P. M. Saw
- Melanoma Institute Australia, The University of Sydney
- David J. Adams
- Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton
- Lu Si
- Department of Renal Cancer and Melanoma, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Cancer Hospital & Institute
- John V. Pearson
- QIMR Berghofer Medical Research Institute
- Nicholas K. Hayward
- QIMR Berghofer Medical Research Institute
- Nicola Waddell
- QIMR Berghofer Medical Research Institute
- Graham J. Mann
- Melanoma Institute Australia, The University of Sydney
- Jun Guo
- Department of Renal Cancer and Melanoma, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Cancer Hospital & Institute
- Richard A. Scolyer
- Melanoma Institute Australia, The University of Sydney
- DOI
- https://doi.org/10.1038/s41467-019-11107-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Mucosal melanomas are challenging to treat partly because so little is known about the genetic drivers underpinning them. Here, the authors perform a genomic landscape analysis of samples collected from three continents, revealing a potential role for CDK4/6 or MEK inhibition in the treatment of the disease.
